Cancer is one of the most fatal diseases of recent times that causes several deaths every
year. The disease variations in different parts of the world, the impact of available medical …

Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

T cell recognition of human leukocyte antigen (HLA)-presented tumor-associated peptides is
central for cancer immune surveillance. Mass spectrometry (MS)-based immunopeptidomics …

The repertoire of naturally presented peptides within the MHC (major histocompatibility
complex) or HLA (human leukocyte antigens) system on the cellular surface of every …

Cancer Immunotherapy relies on harnessing a patient's immune system to fine-tune specific
anti-tumor responses and ultimately eradicate cancer. Among diverse therapeutic …

Malignant pleural mesothelioma (MPM) is an aggressive tumor with a poor prognosis. As the
available therapeutic options show a lack of efficacy, novel therapeutic strategies are …

Central to successful cancer immunotherapy is effective T cell antitumor immunity. Multiple
targeted immunotherapies engineered to invigorate T cell-driven antitumor immunity rely on …

Motivation Including ion mobility separation (IMS) into mass spectrometry proteomics
experiments is useful to improve coverage and throughput. Many IMS devices enable linking …

The immunopeptidome is the repertoire of peptides bound and presented by the MHC class
I, class II, and non-classical molecules. The peptides are produced by the degradation of …

Accurate segmentation of nuclei plays a critical role in pathology since assessments and
diagnoses are mainly based on the recognition, measurement, and counting of nuclei …