Neurobiology of ammonia

V Felipo, RF Butterworth - Progress in neurobiology, 2002 - Elsevier
Hyperammonemia resulting from inherited urea cycle enzyme deficiencies or liver failure
results in severe central nervous system dysfunction including brain edema, convulsions …

Portal hypertension and its complications

AJ Sanyal, J Bosch, A Blei, V Arroyo - Gastroenterology, 2008 - gastrojournal.org
Portal hypertension is a clinical syndrome defined by a portal venous pressure gradient
exceeding 5 mm Hg. 1 Cirrhosis is the most common cause of portal hypertension in the …

Hepatic encephalopathy—definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology …

P Ferenci, A Lockwood, K Mullen, R Tarter… - Hepatology, 2002 - Elsevier
Research on hepatic encephalopathy is hampered by the imprecise definition of this
disabling complication of liver disease. Under this light, the Organisation Mondiale de …

Characteristics of minimal hepatic encephalopathy

P Amodio, S Montagnese, A Gatta, MY Morgan - Metabolic brain disease, 2004 - Springer
The term minimal hepatic encephalopathy refers to the subtle changes in cognitive function,
electrophysiological parameters, cerebral neurochemical/neurotransmitter homeostasis …

Detection of minimal hepatic encephalopathy: normalization and optimization of the Psychometric Hepatic Encephalopathy Score. A neuropsychological and …

P Amodio, F Campagna, S Olianas, P Iannizzi… - Journal of …, 2008 - Elsevier
BACKGROUND/AIMS: Psychometric Hepatic Encephalopathy Score (PHES) and EEG are
used to detect minimal hepatic encephalopathy (MHE). We aimed at standardizing PHES in …

Hepatic encephalopathy: An update of pathophysiologic mechanisms

AS Hazell, RF Butterworth - Proceedings of the society for …, 1999 - Wiley Online Library
Hepatic encephalopathy (HE) is a neuropsychiatric disorder that occurs in both acute and
chronic liver failure. Although the precise pathophysiologic mechanisms responsible for HE …

Complications of cirrhosis III. Hepatic encephalopathy

RF Butterworth - Journal of hepatology, 2000 - Elsevier
Hepatic encephalopathy (HE) is a major neuropsychiatric complication of cirrhosis. HE
develops slowly in cirrhotic patients, starting with altered sleep patterns and eventually …

Neuropsychological characterization and detection of subclinical hepatic encephalopathy

M McCrea, J Cordoba, G Vessey, AT Blei… - Archives of …, 1996 - jamanetwork.com
Objective: To elucidate the nature of the neuropsychological deficits associated with
subclinical hepatic encephalopathy. Design: Prospective study comparing the performance …

Functional anatomy of neuropsychological deficits after severe traumatic brain injury

A Fontaine, P Azouvi, P Remy, B Bussel, Y Samson - Neurology, 1999 - AAN Enterprises
Article Abstract—Background: Neurobehavioral disorders after severe traumatic brain injury
(TBI) are poorly correlated with focal lesions detected by structural neuroimaging techniques …

Methods for diagnosing hepatic encephalopathy in patients with cirrhosis: a multidimensional approach

S Montagnese, P Amodio, MY Morgan - Metabolic brain disease, 2004 - Springer
There is no “gold standard” for diagnosing hepatic encephalopathy in patients with cirrhosis.
In consequence, the presence of this condition, unless floridly overt, is often missed. As a …