Actin is one of the most abundant proteins in eukaryotic cells and the main component of the
microfilament system. It plays essential roles in numerous cellular activities, including …

The cytoskeleton plays important roles in many essential processes at the cellular and
organismal levels, including cell migration and motility, cell division, and the establishment …

According to the cellular actin dynamics paradigm, filaments grow at their barbed ends and
depolymerize predominantly from their pointed ends to form polar structures and do …

Mutations in actin-bundling protein plastin 3 (PLS3) emerged as a cause of congenital
osteoporosis, but neither the role of PLS3 in bone development nor the mechanisms …

Plastins/fimbrins are conserved actin-bundling proteins contributing to motility, cytokinesis
and other cellular processes by organizing strikingly different actin assemblies as in aligned …

Actin-depolymerizing factor (ADF)/cofilins accelerate actin turnover by severing aged actin
filaments and promoting the dissociation of actin subunits. In the cell, ADF/cofilins are …

Actin polymerization dynamics regulated by actin-binding proteins are essential for various
cellular functions. The cofilin family of proteins are potent regulators of actin severing and …

Due to its essential role in cellular processes, actin is a common target for bacterial toxins.
One such toxin, TccC3, is an effector domain of the ABC-toxin produced by …

Multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are pore-forming bacterial
toxins that translocate multiple functionally independent effector domains into a target …

Many Gram-negative bacterial pathogens directly deliver numerous effector proteins from
the bacterium to the host cell, thereby altering the target cell physiology. The already well …