Actin post-translational modifications: the cinderella of cytoskeletal control
Actin is one of the most abundant proteins in eukaryotic cells and the main component of the
microfilament system. It plays essential roles in numerous cellular activities, including …
microfilament system. It plays essential roles in numerous cellular activities, including …
Posttranslational modifications of the cytoskeleton
B MacTaggart, A Kashina - Cytoskeleton, 2021 - Wiley Online Library
The cytoskeleton plays important roles in many essential processes at the cellular and
organismal levels, including cell migration and motility, cell division, and the establishment …
organismal levels, including cell migration and motility, cell division, and the establishment …
Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and VopL
E Kudryashova, Ankita, H Ulrichs, S Shekhar… - Science …, 2022 - science.org
According to the cellular actin dynamics paradigm, filaments grow at their barbed ends and
depolymerize predominantly from their pointed ends to form polar structures and do …
depolymerize predominantly from their pointed ends to form polar structures and do …
Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling
Mutations in actin-bundling protein plastin 3 (PLS3) emerged as a cause of congenital
osteoporosis, but neither the role of PLS3 in bone development nor the mechanisms …
osteoporosis, but neither the role of PLS3 in bone development nor the mechanisms …
Allosteric regulation controls actin-bundling properties of human plastins
CL Schwebach, E Kudryashova, R Agrawal… - Nature structural & …, 2022 - nature.com
Plastins/fimbrins are conserved actin-bundling proteins contributing to motility, cytokinesis
and other cellular processes by organizing strikingly different actin assemblies as in aligned …
and other cellular processes by organizing strikingly different actin assemblies as in aligned …
Oligomerization affects the ability of human cyclase-associated proteins 1 and 2 to promote actin severing by cofilins
Actin-depolymerizing factor (ADF)/cofilins accelerate actin turnover by severing aged actin
filaments and promoting the dissociation of actin subunits. In the cell, ADF/cofilins are …
filaments and promoting the dissociation of actin subunits. In the cell, ADF/cofilins are …
Magic angle spinning NMR structure of human cofilin-2 assembled on actin filaments reveals isoform-specific conformation and binding mode
Actin polymerization dynamics regulated by actin-binding proteins are essential for various
cellular functions. The cofilin family of proteins are potent regulators of actin severing and …
cellular functions. The cofilin family of proteins are potent regulators of actin severing and …
Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity
S Dong, W Zheng, N Pinkerton, J Hansen… - International journal of …, 2022 - mdpi.com
Due to its essential role in cellular processes, actin is a common target for bacterial toxins.
One such toxin, TccC3, is an effector domain of the ABC-toxin produced by …
One such toxin, TccC3, is an effector domain of the ABC-toxin produced by …
The Vibrio cholerae MARTX toxin silences the inflammatory response to cytoskeletal damage before inducing actin cytoskeleton collapse
PJ Woida, KJF Satchell - Science signaling, 2020 - science.org
Multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are pore-forming bacterial
toxins that translocate multiple functionally independent effector domains into a target …
toxins that translocate multiple functionally independent effector domains into a target …
The modes of action of MARTX toxin effector domains
BS Kim - Toxins, 2018 - mdpi.com
Many Gram-negative bacterial pathogens directly deliver numerous effector proteins from
the bacterium to the host cell, thereby altering the target cell physiology. The already well …
the bacterium to the host cell, thereby altering the target cell physiology. The already well …