Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Cardiovascular disorders are leading mortality causes worldwide, often with a latent
evolution. Vascular health depends on endothelial function, arterial stiffness, and the …

Arterial stiffness is a strong predictor of cardiovascular events and all-cause mortality in
middle-aged and old adults. Arterial stiffness has been limited to being an intermediate …

Structural and functional arterial properties commonly impair with aging process. These
effects on vasculature could act at many levels from microcirculation to large vessels. Above …

In the arteries of vertebrates, evolution has given rise to resilient macromolecular structures,
elastin and elastic fibers, capable of sustaining an elevated blood pressure and …

Vascular age is an emerging field in cardiovascular risk assessment. This concept includes
multifactorial changes in the arterial wall, with arterial stiffness as its most relevant …

Atherosclerosis is the most common cause of cardiac deaths worldwide. Classically,
atherosclerosis has been explained as a simple arterial lipid deposition with concomitant …

Objective Arterial stiffness is an early and detectable marker of vascular changes leading to
atherosclerotic cardiovascular disease (ACVD). Our objective was to compare the …

Vascular calcification is a ubiquitous pathology of aging. Oxidative stress, persistent DNA
damage, and senescence are major pathways driving both cellular and tissue aging, and …

The exact link between obesity, vitamin D deficiency, and their relation to cellular
senescence in the pathogenesis of subclinical atherosclerosis is still under debate …