Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

Abstract Background In Uganda, artemether-lumefantrine is recommended for malaria
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …

Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …

Background Sub-Saharan Africa has the highest burden of malaria in the world. Artemisinin-
based combination therapies (ACTs) have been the cornerstone in the efforts to reduce the …

Background Treatment and control of malaria depends on artemisinin-based combination
therapies (ACTs) and is challenged by drug resistance, but thus far resistance to …

Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the
development of new antimalarials. Experience with clinical candidate triazolopyrimidine …

We describe noncovalent, reversible asparagine ethylenediamine (AsnEDA) inhibitors of the
Plasmodium falciparum proteasome (Pf20S) β5 subunit that spare all active subunits of …

Osteolysis is an osteolytic lesion featured by enhanced osteoclast formation and potent
bone erosion. Lacking of effective regimen for treatment of the pathological process …

Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …