Massive annotation of bacterial L-asparaginases reveals their puzzling distribution and frequent...

AN Shishparenok, YA Gladilina… - International Journal of …, 2023 - mdpi.com

Genetic engineering for heterologous expression has advanced in recent years. Model
systems such as Escherichia coli, Bacillus subtilis and Pichia pastoris are often used as host …

被引用次数：4 相关文章所有 7 个版本

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Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center

JI Loch, P Worsztynowicz, J Sliwiak… - … Section D: Structural …, 2023 - journals.iucr.org

The genome of Rhizobium etli, a nitrogen-fixing bacterial symbiont of legume plants,
encodes two l-asparaginases, ReAIV and ReAV, that have no similarity to the well …

被引用次数：6 相关文章所有 9 个版本

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The effects of nature‐inspired amino acid substitutions on structural and biochemical properties of the E. coli L‐asparaginase EcAIII

M Janicki, A Ściuk, A Zielezinski, M Ruszkowski… - Protein …, 2023 - Wiley Online Library

Abstract The Escherichia coli enzyme EcAIII catalyzes the hydrolysis of L‐Asn to L‐Asp and
ammonia. Using a nature‐inspired mutagenesis approach, we designed and produced five …

被引用次数：5 相关文章所有 9 个版本

[PDF] wiley.com

RrA, an enzyme from Rhodospirillum rubrum, is a prototype of a new family of short‐chain L‐asparaginases

D Zhang, H Czapinska, M Bochtler… - Protein …, 2024 - Wiley Online Library

L‐Asparaginases (ASNases) catalyze the hydrolysis of L‐Asn to L‐Asp and ammonia.
Members of the ASNase family are used as drugs in the treatment of leukemia, as well as in …

Probing the active site of Class 3 L-asparaginase by mutagenesis. I. Tinkering with the zinc coordination site of ReAV

K Pokrywka, M Grzechowiak, J Sliwiak… - Frontiers in …, 2024 - frontiersin.org

ReAV, the inducible Class-3 L-asparaginase from the nitrogen-fixing symbiotic bacterium
Rhizobium etli, is an interesting candidate for optimizing its enzymatic potential for …

The structural insights of L-asparaginase from Pseudomonas aeruginosa CSPS4 at elevated temperatures highlight its thermophilic nature

V Kumar, P Anand, A Srivastava, Y Akhter, D Verma - 3 Biotech, 2024 - Springer

In the present investigation, a novel thermophilic L-asparaginase (Asn_PA) from
Pseudomonas aeruginosa CSPS4 was investigated to explore its structural insights at …

l‐Asparaginase Bio‐Betters: Insight Into Current Formulations, Optimization Strategies and Future Bioengineering Frontiers in Anti‐Cancer Drug Development

S Sonowal, K Pathak, D Das, K Buragohain… - Advanced … - Wiley Online Library

Cancer remains a persistent global health concern, representing a significant challenge in
medical science and patient care. In this context, l‐asparaginase has emerged as a …

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