This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

The coronavirus disease 2019 (COVID-19) pandemic is caused by an infectious novel strain
of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

The emergence of pathogens resistant to conventional antibiotics and the growing interest in
developing alternative natural antimicrobial agents have prompted a search for plant …

For millennia, humanity has relied on plants for its medicines, and modern pharmacology
continues to reexamine and mine plant metabolites for novel compounds and to guide …

Cyclotides are a novel class of micro-proteins (≈ 30–40 residues long) with a unique
topology containing a head-to-tail cyclized backbone structure further stabilized by three …

Background Malaria still constitutes a major public health menace, especially in tropical and
subtropical countries. Close to half a million people mainly children in Africa, die every year …

Pharmacopoeias are important resources for the quality control of medicinal plants and their
products. Considering that approximately 80% of the world population to different extents …

Parasites are scarcely addressed target for antimicrobial peptides despite their big impact in
health and global economy. The notion of antimicrobial peptides is frequently associated to …

Oral activity has been described for cyclotide-containing traditional medicines, and
demonstrated for reengineered cyclotides bearing grafted therapeutic epitopes, highlighting …

The Oldenlandia genus comprises approximately 240 species of plants, yet only a limited
number of these have been investigated for their chemical composition and medicinal …