CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25
The calcitonin/CGRP family of peptides includes calcitonin, α and β CGRP, amylin,
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …
adrenomedullin (AM) and adrenomedullin 2/intermedin (AM2/IMD). Their receptors consist …
[HTML][HTML] Shared and independent roles of CGRP and PACAP in migraine pathophysiology
A Kuburas, AF Russo - The Journal of Headache and Pain, 2023 - Springer
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a
major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the …
major role in sensory neurotransmission. The CGRP receptor is a heterodimer of the …
Combinatorial expression of GPCR isoforms affects signalling and drug responses
M Marti-Solano, SE Crilly, D Malinverni, C Munk… - Nature, 2020 - nature.com
G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology
across human tissues in response to extracellular signals. GPCR-mediated signalling can …
across human tissues in response to extracellular signals. GPCR-mediated signalling can …
[HTML][HTML] The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects
Z Kee, X Kodji, SD Brain - Frontiers in physiology, 2018 - frontiersin.org
Calcitonin gene-related peptide (CGRP) is a highly potent vasoactive peptide released from
sensory nerves, which is now proposed to have protective effects in several cardiovascular …
sensory nerves, which is now proposed to have protective effects in several cardiovascular …
Migraine therapeutics differentially modulate the CGRP pathway
M Bhakta, T Vuong, T Taura, DS Wilson… - …, 2021 - journals.sagepub.com
Background The clinical efficacy of migraine therapeutic agents directed towards the
calcitonin-gene related peptide (CGRP) pathway has confirmed the key role of this axis in …
calcitonin-gene related peptide (CGRP) pathway has confirmed the key role of this axis in …
Elucidating the interactome of G protein-coupled receptors and receptor activity-modifying proteins
G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …
integral membrane proteins that modulate their biology and pharmacology. However, the …
The activity of peptides of the calcitonin family in bone
Calcitonin was discovered over 50 yr ago as a new hormone that rapidly lowers circulating
calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as …
calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as …
Don't stress about CRF: assessing the translational failures of CRF1antagonists
SR Spierling, EP Zorrilla - Psychopharmacology, 2017 - Springer
Abstract Background Dr. Athina Markou sought treatments for a common neural substrate
shared by depression and drug dependence. Antagonists of corticotropin-releasing factor …
shared by depression and drug dependence. Antagonists of corticotropin-releasing factor …