Diabetes mellitus is one of the major public health problems worldwide. Considerable recent
evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative …

Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …

Amplification of oxidative stress is present since the early stages of chronic kidney disease
(CKD), holding a key position in the pathogenesis of renal failure. Induction of renal pro …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Simple Summary The progressive nature of type 2 diabetes mellitus (T2DM) leads to micro-
and macro-vascular complications, including renal and cardiovascular disease. These …

Diabetes induces the onset and progression of renal injury through causing hemodynamic
dysregulation along with abnormal morphological and functional nephron changes. The …

Diabetic nephropathy (DN), a chronic complication of diabetes, is charecterized by
glomerular hypertrophy, proteinuria, decreased glomerular filtration, and renal fibrosis …

Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …

Chronic renal and vascular oxidative stress in association with an enhanced inflammatory
burden are determinant processes in the development and progression of diabetic …

Reactive oxygen species (ROS) generated by Nox NADPH oxidases may play a critical role
in the pathogenesis of diabetic nephropathy (DN). The efficacy of the Nox1/Nox4 inhibitor …