Salts of therapeutic agents: chemical, physicochemical, and biological considerations

D Gupta, D Bhatia, V Dave, V Sutariya… - Molecules, 2018 - mdpi.com
The physicochemical and biological properties of active pharmaceutical ingredients (APIs)
are greatly affected by their salt forms. The choice of a particular salt formulation is based on …

Cocrystals by design: a rational coformer selection approach for tackling the API problems

M Singh, H Barua, VGSS Jyothi, MR Dhondale… - Pharmaceutics, 2023 - mdpi.com
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

Crystal and particle engineering strategies for improving powder compression and flow properties to enable continuous tablet manufacturing by direct compression

S Chattoraj, CC Sun - Journal of pharmaceutical sciences, 2018 - Elsevier
Continuous manufacturing of tablets has many advantages, including batch size flexibility,
demand-adaptive scale up or scale down, consistent product quality, small operational foot …

Superior plasticity and tabletability of theophylline monohydrate

SY Chang, CC Sun - Molecular pharmaceutics, 2017 - ACS Publications
A theophylline monohydrate (THm) powder, with particle size and shape substantially
similar to a theophylline anhydrate powder, was prepared by vapor-mediated phase …

Cocrystals; basic concepts, properties and formation strategies

S Khan, M Zahoor, MU Rahman, Z Gul - Zeitschrift für Physikalische …, 2023 - degruyter.com
Cocrystallization is an old technique and remains the focus of several research groups
working in the field of Chemistry and Pharmacy. This technique is basically in field for …

Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes

KM Hutchins - Royal Society open science, 2018 - royalsocietypublishing.org
The design, synthesis and property characterization of new functional materials has
garnered interest in a variety of fields. Materials that are capable of recognizing and binding …

X-ray crystallography and its role in understanding the physicochemical properties of pharmaceutical cocrystals

S Aitipamula, VR Vangala - Journal of the Indian Institute of Science, 2017 - Springer
Abstract Properties of a matter are intrinsically dependent on the internal arrangement of
molecules in the solid state. Therefore, knowledge of three-dimensional structure of the …

Obtaining cocrystals by reaction crystallization method: Pharmaceutical applications

IFB Biscaia, SN Gomes, LS Bernardi, PR Oliveira - Pharmaceutics, 2021 - mdpi.com
Cocrystals have gained attention in the pharmaceutical industry due to their ability to
improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble …

Tadalafil–malonic acid cocrystal: Physicochemical characterization, pH-solubility, and supersaturation studies

MR Shimpi, A Alhayali, KL Cavanagh… - Crystal Growth & …, 2018 - ACS Publications
The purpose of this study was to enhance the solubility and dissolution of a poorly water-
soluble drug, tadalafil (TDF), by cocrystal formation with malonic acid (MOA), to characterize …

[HTML][HTML] Salt hydrates in renewable energy systems: A thorough review

MM Ghafurian, B Elmegaard, P Weinberger… - Energy, 2024 - Elsevier
This paper aims to review recent advancements in the utilization, storage, and integration of
salt hydrates (SHs) in renewable energy (RE) systems. Initially, the latest review articles on …