Salts of therapeutic agents: chemical, physicochemical, and biological considerations
The physicochemical and biological properties of active pharmaceutical ingredients (APIs)
are greatly affected by their salt forms. The choice of a particular salt formulation is based on …
are greatly affected by their salt forms. The choice of a particular salt formulation is based on …
Cocrystals by design: a rational coformer selection approach for tackling the API problems
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …
stability present a significant challenge during their processing into final dosage forms …
Crystal and particle engineering strategies for improving powder compression and flow properties to enable continuous tablet manufacturing by direct compression
S Chattoraj, CC Sun - Journal of pharmaceutical sciences, 2018 - Elsevier
Continuous manufacturing of tablets has many advantages, including batch size flexibility,
demand-adaptive scale up or scale down, consistent product quality, small operational foot …
demand-adaptive scale up or scale down, consistent product quality, small operational foot …
Superior plasticity and tabletability of theophylline monohydrate
SY Chang, CC Sun - Molecular pharmaceutics, 2017 - ACS Publications
A theophylline monohydrate (THm) powder, with particle size and shape substantially
similar to a theophylline anhydrate powder, was prepared by vapor-mediated phase …
similar to a theophylline anhydrate powder, was prepared by vapor-mediated phase …
Cocrystals; basic concepts, properties and formation strategies
Cocrystallization is an old technique and remains the focus of several research groups
working in the field of Chemistry and Pharmacy. This technique is basically in field for …
working in the field of Chemistry and Pharmacy. This technique is basically in field for …
Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes
KM Hutchins - Royal Society open science, 2018 - royalsocietypublishing.org
The design, synthesis and property characterization of new functional materials has
garnered interest in a variety of fields. Materials that are capable of recognizing and binding …
garnered interest in a variety of fields. Materials that are capable of recognizing and binding …
X-ray crystallography and its role in understanding the physicochemical properties of pharmaceutical cocrystals
S Aitipamula, VR Vangala - Journal of the Indian Institute of Science, 2017 - Springer
Abstract Properties of a matter are intrinsically dependent on the internal arrangement of
molecules in the solid state. Therefore, knowledge of three-dimensional structure of the …
molecules in the solid state. Therefore, knowledge of three-dimensional structure of the …
Obtaining cocrystals by reaction crystallization method: Pharmaceutical applications
IFB Biscaia, SN Gomes, LS Bernardi, PR Oliveira - Pharmaceutics, 2021 - mdpi.com
Cocrystals have gained attention in the pharmaceutical industry due to their ability to
improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble …
improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble …
Tadalafil–malonic acid cocrystal: Physicochemical characterization, pH-solubility, and supersaturation studies
The purpose of this study was to enhance the solubility and dissolution of a poorly water-
soluble drug, tadalafil (TDF), by cocrystal formation with malonic acid (MOA), to characterize …
soluble drug, tadalafil (TDF), by cocrystal formation with malonic acid (MOA), to characterize …
[HTML][HTML] Salt hydrates in renewable energy systems: A thorough review
This paper aims to review recent advancements in the utilization, storage, and integration of
salt hydrates (SHs) in renewable energy (RE) systems. Initially, the latest review articles on …
salt hydrates (SHs) in renewable energy (RE) systems. Initially, the latest review articles on …