Recently, immune checkpoint inhibitors (ICIs) therapy has become a promising therapeutic
strategy with encouraging therapeutic outcomes due to their durable anti-tumor effects …

Investigations into the interaction between radiotherapy and the host immune system have
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …

Background Immunotherapy is at the forefront of modern oncologic care. Various novel
therapies have targeted all three layers of tumor biology: tumor, niche, and immune system …

Importance Oncolytic viruses (OVs) are emerging as important agents in cancer treatment.
Oncolytic viruses offer the attractive therapeutic combination of tumor-specific cell lysis …

Background Ipilimumab is a fully human monoclonal antibody that binds cytotoxic T-
lymphocyte antigen 4 to enhance antitumour immunity. Our aim was to assess the use of …

The toxicities of immunotherapy for cancer are as diverse as the type of treatments that have
been devised. These range from cytokine therapies that induce capillary leakage to …

Background The phase 3 trial CA184-043 evaluated radiotherapy to bone metastases
followed by Ipilimumab or placebo in men with metastatic castrate-resistant prostate cancer …

The genetic and cellular alterations that define cancer provide the immune system with the
means to generate T cell responses that recognize and eradicate cancer cells. However …

Recent clinical data have emphatically shown the capacity of our immune systems to
eradicate even advanced cancers. Although oncolytic viruses (OVs) were originally …

Therapies using T cells that are programmed to express chimeric antigen receptors (CAR T
cells) consistently produce positive results in patients with hematologic malignancies …