T cells in abdominal aortic aneurysm: immunomodulation and clinical application
W Gong, Y Tian, L Li - Frontiers in Immunology, 2023 - frontiersin.org
Abdominal aortic aneurysm (AAA) is characterized by inflammatory cell infiltration,
extracellular matrix (ECM) degradation, and vascular smooth muscle cell (SMC) dysfunction …
extracellular matrix (ECM) degradation, and vascular smooth muscle cell (SMC) dysfunction …
[HTML][HTML] The role of immune mechanisms in abdominal aortic aneurysm: could it be a promising therapeutic strategy?
R Dinc - Acta Cardiologica Sinica, 2023 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) is an enlargement of the aorta greater than 50% in
diameter. Although up to 80% of cases result in mortality if the aneurysm ruptures, patients …
diameter. Although up to 80% of cases result in mortality if the aneurysm ruptures, patients …
ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm …
To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
A role of inflammaging in aortic aneurysm: new insights from bioinformatics analysis
S Wang, H Liu, P Yang, Z Wang, P Ye, J Xia… - Frontiers in …, 2023 - frontiersin.org
Introduction Aortic aneurysms (AA) are prevalent worldwide with a notable absence of drug
therapies. Thus, identifying potential drug targets is of utmost importance. AA often presents …
therapies. Thus, identifying potential drug targets is of utmost importance. AA often presents …
Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans …
Introduction Vascular smooth muscle cells (VSMCs) are the predominant cell type in the
medial layer of the aorta, which plays a critical role in aortic diseases. Innate immunity is the …
medial layer of the aorta, which plays a critical role in aortic diseases. Innate immunity is the …
[HTML][HTML] Integrative analysis of single-Cell RNA sequencing and experimental validation in the study of abdominal aortic aneurysm progression
J Xiong, G Chen, B Lin, L Zhong, X Jiang, H Lu - Gene, 2024 - Elsevier
Background Abdominal aortic aneurysm (AAA) is a complex vascular disorder characterized
by the progressive dilation of the abdominal aorta, with a high risk of rupture and mortality …
by the progressive dilation of the abdominal aorta, with a high risk of rupture and mortality …
[HTML][HTML] PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm
Y Xiong, S Liu, Y Liu, J Zhao, J Sun, Y Li, B Pan… - JCI insight, 2024 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) is one of the most life-threatening cardiovascular
diseases; however, effective drug treatments are still lacking. The formation of neutrophil …
diseases; however, effective drug treatments are still lacking. The formation of neutrophil …
Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics
J Hu, S Xue, Z Xu, Z Wu, X Xu, X Wang, G Liu… - Frontiers in …, 2023 - frontiersin.org
Background The occurrence of abdominal aortic aneurysms (AAAs) is related to the disorder
of immune microenvironment. Cuprotosis was reported to influence the immune …
of immune microenvironment. Cuprotosis was reported to influence the immune …
Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
R Chen, H Zhang, B Tang, Y Luo, Y Yang… - … and Targeted Therapy, 2024 - nature.com
The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …
multifunctional cells of the innate immune system, macrophages play an essential role in …
Global research status analysis of the association between aortic aneurysm and inflammation: a bibliometric analysis from 1999 to 2023
Q Wang, G Chen, Z Qi, Y Zeng, L Tan… - Frontiers in …, 2023 - frontiersin.org
Background Aortic aneurysm is a chronic arterial disease that can lead to aortic rupture,
causing severe complications and life-threatening risks for patients, and it is one of the …
causing severe complications and life-threatening risks for patients, and it is one of the …