[HTML][HTML] Tug-of-war via ERK signaling pathway for tissue organization–ERK activation to force generation

AN Nayak, T Hirashima - Current Opinion in Cell Biology, 2023 - Elsevier
Extracellular signal-regulated kinase (ERK) plays a crucial role in regulating collective cell
behaviors observed in diverse biological phenomena. Emerging studies have shed light on …

Mechanics of neural tube morphogenesis

LD Moon, F Xiong - Seminars in Cell & Developmental Biology, 2022 - Elsevier
The neural tube is an important model system of morphogenesis representing the
developmental module of out-of-plane epithelial deformation. As the embryonic precursor of …

[HTML][HTML] Optogenetic activators of apoptosis, necroptosis, and pyroptosis

K Shkarina, E Hasel de Carvalho, JC Santos… - Journal of Cell …, 2022 - rupress.org
Targeted and specific induction of cell death in an individual or groups of cells hold the
potential for new insights into the response of tissues or organisms to different forms of …

Impact of separate concentrations of polyethylene microplastics on the ability of pollutants removal during the operation of constructed wetland-microbial fuel cell

Y Yuan, C Leng, Y Zhou, Y Yuan, Y Niu, R Xu… - Journal of …, 2023 - Elsevier
Microplastics (MPs) in water pose a great threat to the ecological environment, but the
impact of MPs on constructed wetland microbial fuel cells (CW-MFCs) has not been studied …

Epithelial apoptotic pattern emerges from global and local regulation by cell apical area

VML Cachoux, M Balakireva, M Gracia, F Bosveld… - Current Biology, 2023 - cell.com
Geometry is a fundamental attribute of biological systems, and it underlies cell and tissue
dynamics. Cell geometry controls cell-cycle progression and mitosis and thus modulates …

Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia

K Duszyc, JB von Pein, D Ramnath, D Currin-Ross… - Developmental Cell, 2023 - cell.com
Apoptosis is traditionally considered to be an immunologically silent form of cell death.
Multiple mechanisms exist to ensure that apoptosis does not stimulate the immune system to …

Interfacial organization and forces arising from epithelial–cancerous monolayer interactions

LY Guan, SZ Lin, PC Chen, JQ Lv, B Li, XQ Feng - ACS nano, 2023 - ACS Publications
The interfacial interactions between epithelia and cancer cells have profound relevance for
tumor development and metastasis. Through monolayer confrontation of MCF10A …

Collective effects in epithelial cell death and cell extrusion

A Villars, R Levayer - Current opinion in genetics & development, 2022 - Elsevier
Programmed cell death, notably apoptosis, is an essential guardian of tissue homeostasis
and an active contributor of organ shaping. While the regulation of apoptosis has been …

Apoptotic extracellular vesicle formation via local phosphatidylserine exposure drives efficient cell extrusion

A Kira, I Tatsutomi, K Saito, M Murata, I Hattori… - Developmental Cell, 2023 - cell.com
Cell extrusion is a universal mode of cell removal from tissues, and it plays an important role
in regulating cell numbers and eliminating unwanted cells. However, the underlying …

[HTML][HTML] A sustained calcium response mediated by IP3 receptor anchoring to the desmosome is essential for apoptotic cell elimination

Y Cho, I Koyama-Honda, A Tanimura, K Matsuzawa… - Current Biology, 2024 - cell.com
Efficient elimination of apoptotic cells within epithelial cell sheets is crucial for preserving
epithelial barrier integrity. 1 It is well established that immediate neighbors of an apoptotic …