Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional
communication between the gut and the brain suggesting that the gut microbes may shape …

Probiotics have been considered as an economical and safe alternative for the treatment of
a large number of chronic diseases and improvement of human health. They are known to …

The plasma proteome can help bridge the gap between the genome and diseases. Here we
describe genome-wide association studies (GWASs) of plasma protein levels measured with …

Trait-associated genetic variants affect complex phenotypes primarily via regulatory
mechanisms on the transcriptome. To investigate the genetics of gene expression, we …

The gene-regulatory landscape of the brain is highly dynamic in health and disease,
coordinating a menagerie of biological processes across distinct cell types. Here, we …

Genome-wide association studies (GWAS) have identified thousands of noncoding loci that
are associated with human diseases and complex traits, each of which could reveal insights …

High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …

Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …

Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …

Ulcerative colitis (UC) is a chronic immune-mediated inflammatory disorder of the colon
(IBD) that is hypothesized to be related to exposure to environmental risk factors leading to …