GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Adenosine is formed inside cells or on their surface, mostly by breakdown of adenine
nucleotides. The formation of adenosine increases in different conditions of stress and …

Adenosine is a ubiquitous extracellular signaling molecule with essential functions in human
physiology. Due to the widespread expression of adenosine receptors, it has far-reaching …

Objectives: The purpose of this research was to determine the effect of intravenous
adenosine on clinical outcomes and infarct size in ST-segment elevation myocardial …

Nucleotides and nucleosides influence nearly every aspect of physiology and
pathophysiology. Extracellular nucleotides are metabolized through regulated …

Cxs (connexins), the protein subunits forming gap junction intercellular communication
channels, are transported to the plasma membrane after oligomerizing into hexameric …

▪ Abstract Adenosine and its receptors have been the topic of many recent reviews (–).
These reviews provide a good summary of much of the relevant literature—including the …

Objective: This study tested the hypothesis that brief cycles of iterative ischemia–reperfusion
at onset of reperfusion (termed “postconditioning”, post-con) delays washout of intravascular …

The 5′-nucleotidases are a family of enzymes that catalyze the dephosphorylation of
nucleoside monophosphates and regulate cellular nucleotide and nucleoside levels. While …

At rest the myocardium extracts∼ 75% of the oxygen delivered by coronary blood flow. Thus
there is little extraction reserve when myocardial oxygen consumption is augmented …