Breast cancer is the most frequently diagnosed cancer in women, with estrogen receptor
positive (ER+) breast cancer making up approximately 75% of all breast cancers diagnosed …

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …

Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer
(mCRPC) samples, we identified a novel subtype of prostate cancer typified by biallelic loss …

Abstract Background The PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations
and PTEN loss in breast cancer. We conducted a phase II trial with an allosteric AKT …

Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose
tissue is generally linked to excessive body fat, and it is well known that the female breast is …

Simple Summary PI3K signaling pathway plays an essential role in many cellular processes
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …

Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …

Purpose Clinicopathologic features and biochemical recurrence are sensitive, but not
specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a …

Tamoxifen remains the most effective treatment for estrogen receptor α (ERα)‐positive
breast cancer. However, many patients still develop resistance to tamoxifen in association …

Prostate cancer is characterized by its dependence on androgen receptor (AR) and frequent
activation of PI3K signaling. We find that AR transcriptional output is decreased in human …