Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Notch signaling is an evolutionarily conserved pathway that regulates important biological
processes, such as cell proliferation, apoptosis, migration, self-renewal, and differentiation …

The poor prognosis and rapid recurrence of glioblastoma (GB) are associated to its fast-
growing process and invasive nature, which make difficult the complete removal of the …

The androgen receptor (AR) has been linked to bladder cancer (BC a) progression, but if
this involves circular RNA s (circ RNA s) remains unclear. Here, we find that AR alters the …

Background: The tumor microenvironment (TME) plays a crucial role in virtually every aspect
of tumorigenesis of glioblastoma multiforme (GBM). A dysfunctional TME promotes drug …

A frequent observation in several malignancies is the development of resistance to therapy
that results in frequent tumor relapse and metastasis. Much of the tumor resistance …

Glioblastoma (GBM) is the most malignant tumor in brain and is highly resistant to therapy.
Clinical evidence suggests increased number of cancer stem cells (CSCs) may contribute to …

Glioblastoma multiforme (GBM) is an aggressive brain cancer showing poor prognosis.
Currently, treatment methods of GBM are limited with adverse outcomes and low survival …

Interaction between a tumor and its microenvironment is important for tumor initiation and
progression. Cancer stem cells (CSCs) within the tumor interact with a microenvironmental …

Neural stem cells (NSCs) give rise to the central nervous system (CNS) and persist in certain
areas of adult brains for replenishing damaged differentiated cells. The loss of the balance …