Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Most general anaesthetics and classical benzodiazepine drugs act through positive
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …

Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …

Ketamine is used clinically as an anaesthetic and a fast-acting antidepressant, and
recreationally for its dissociative properties, raising concerns of addiction as a possible side …

A basic feature of intelligent systems such as the cerebral cortex is the ability to freely
associate aspects of perceived experience with an internal representation of the world and …

Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Recently it was demonstrated that exposure of the developing brain during the period of
synaptogenesis to drugs that block NMDA glutamate receptors or drugs that potentiate …

The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …