The cytochrome P450 (CYP) superfamily constitutes a collection of enzymes responsible for
the metabolism of a wide array of endo-and xenobiotic compounds. Much of the knowledge …

976 TREPANIER into inactive metabolites (eg, warfarin, phenytoin), bioactivate prodrugs
into active drugs (eg, codeine, tramadol, enalapril), or generate reactive toxic metabolites …

The pharmacokinetics of celecoxib, a cyclooxygenase-2 inhibitor, was characterized in
beagle dogs. Celecoxib is extensively metabolized by dogs to a hydroxymethyl metabolite …

CYP2D15 is the canine ortholog of human CYP2D6, the human CYP2D isoform involved in
the metabolism of drugs such as antiarhythmics, adrenoceptor antagonists, and tricyclic …

CYP2D15 is a major drug metabolizing P450 in canine liver. Like the human orthologue
(CYP2D6), this enzyme is highly polymorphic with at least five common nonsynonymous …

Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic
pathways and are classified in various superfamilies. The CYP, or P450, superfamily …

Drug oxygenation is mainly mediated by cytochromes P450 (P450s, CYPs) and flavin-
containing monooxygenases (FMOs). Polymorphic variants of P450s and FMOs are known …

A number of human cytochrome P450 (CYP) isozymes have been shown to be genetically
polymorphic, and extensive pharmaceutical studies have been conducted to characterize …

The CYP3 Family | Cytochromes P450: Role in the Metabolism and Toxicity of Drugs and other
Xenobiotics | Books Gateway | Royal Society of Chemistry Skip to Main Content Umbrella Alt …

Cytochrome P450 2D (CYP2D) is one of the major metabolizing enzymes for drugs in
humans and other mammals. Although domestic cats (Felis catus) are the most common …