Ventricular wall biomaterial injection therapy after myocardial infarction: Advances in material design, mechanistic insight and early clinical experiences
Intramyocardial biomaterial injection therapy for myocardial infarction has made significant
progress since concept initiation more than 10 years ago. The interim successes and …
progress since concept initiation more than 10 years ago. The interim successes and …
Micro-and nanoscale biophysical cues for cardiovascular disease therapy
P Mohindra, TA Desai - Nanomedicine: Nanotechnology, Biology and …, 2021 - Elsevier
After cardiovascular injury, numerous pathological processes adversely impact the
homeostatic function of cardiomyocyte, macrophage, fibroblast, endothelial cell, and …
homeostatic function of cardiomyocyte, macrophage, fibroblast, endothelial cell, and …
Injectable hyaluronic acid based microrods provide local micromechanical and biochemical cues to attenuate cardiac fibrosis after myocardial infarction
LV Le, P Mohindra, Q Fang, RE Sievers, MA Mkrtschjan… - Biomaterials, 2018 - Elsevier
Repairing cardiac tissue after myocardial infarction (MI) is one of the most challenging goals
in tissue engineering. Following ischemic injury, significant matrix remodeling and the …
in tissue engineering. Following ischemic injury, significant matrix remodeling and the …
Local decorin delivery via hyaluronic acid microrods improves cardiac performance, ventricular remodeling after myocardial infarction
Heart failure (HF) remains a global public health burden and often results following
myocardial infarction (MI). Following injury, cardiac fibrosis forms in the myocardium which …
myocardial infarction (MI). Following injury, cardiac fibrosis forms in the myocardium which …
Human intestinal spheroids cultured using Sacrificial Micromolding as a model system for studying drug transport
In vitro models of the small intestine are crucial tools for the prediction of drug absorption.
The Caco-2 monolayer transwell model has been widely employed to assess drug …
The Caco-2 monolayer transwell model has been widely employed to assess drug …
Biofluid‐triggered burst release from an adaptive covalently assembled dipeptide nanocontainer for emergency treatment
J Fei, H Zhang, A Wang, C Qin… - Advanced Healthcare …, 2017 - Wiley Online Library
The construction of quickly dissociating containers holding bioactive components that meet
the extreme requirements of emergency treatment is highly desirable but remains a great …
the extreme requirements of emergency treatment is highly desirable but remains a great …
Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction
The Insulin like growth factor-I isoform mechano-growth factor (MGF), is expressed in the
heart following myocardial infarction and encodes a unique E-domain region. To examine E …
heart following myocardial infarction and encodes a unique E-domain region. To examine E …
Concise review: reduction of adverse cardiac scarring facilitates pluripotent stem cell-based therapy for myocardial infarction
Pluripotent stem cells (PSCs) are an attractive, reliable source for generating functional
cardiomyocytes for regeneration of infarcted heart. However, inefficient cell engraftment into …
cardiomyocytes for regeneration of infarcted heart. However, inefficient cell engraftment into …
Prenatal exposure to lipopolysaccharide results in myocardial fibrosis in rat offspring
X Chen, Y Tang, M Gao, S Qin, J Zhou, X Li - International journal of …, 2015 - mdpi.com
The epigenetic plasticity hypothesis indicates that exposure during pregnancy may cause
adult-onset disorders, including hypertension, myocardial infarction and heart failure …
adult-onset disorders, including hypertension, myocardial infarction and heart failure …
Hang on tight: reprogramming the cell with microstructural cues
Cells interact intimately with complex microdomains in their extracellular matrix (ECM) and
maintain a delicate balance of mechanical forces through mechanosensitive cellular …
maintain a delicate balance of mechanical forces through mechanosensitive cellular …