Mammalian females have two X chromosomes and males have only one. This has led to the
evolution of special mechanisms of dosage compensation. The inactivation of one X …

The relatively new field of phylogenomics is beginning to reveal the potential of genomic
data for evolutionary studies. As the cost of whole genome sequencing falls, anticipation of …

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum
(Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the …

The Xist noncoding RNA is the key initiator of the process of X chromosome inactivation in
eutherian mammals, but its precise function and origin remain unknown. Although Xist is …

▪ Abstract Mammalian X chromosome inactivation is one of the most striking examples of
epigenetic gene regulation. Early in development one of the pair of∼ 160-Mb X …

X-chromosome inactivation is a remarkable epigenetic event in mammalian females that
results in the transcriptional silencing of one of the pair of X chromosomes. However, not all …

This article explores the major design characteristics (both pedagogic as well as technical)
that helped to shape Alice 2. It identifies several strengths of Alice as well as several …

Mechanisms of vertebrate sex determination are reviewed in the light of what is known about
the origin and evolution of sex chromosomes. All vertebrate males have testes that are …

Morphological data supports monotremes as the sister group of Theria (extant marsupials+
eutherians), but phylogenetic analyses of 12 mitochondrial protein-coding genes have …

Background The DAZ family genes boule, daz and dazl encode RNA binding proteins
essential for fertility of diverse animals including human. dazl has bisexual expression in …