Metabolic therapy of heart failure: Is there a future for B vitamins?

J Piquereau, SE Boitard, R Ventura-Clapier… - International Journal of …, 2021 - mdpi.com
Heart failure (HF) is a plague of the aging population in industrialized countries that
continues to cause many deaths despite intensive research into more effective treatments …

Impaired coenzyme A homeostasis in cardiac dysfunction and benefits of boosting coenzyme A production with vitamin B5 and its derivatives in the management of …

JJ Wedman, OCM Sibon… - Journal of Inherited …, 2024 - Wiley Online Library
Coenzyme A (CoA) is an essential cofactor required for over a hundred metabolic reactions
in the human body. This cofactor is synthesized de novo in our cells from vitamin B5, also …

Dexpanthenol attenuates inflammatory damage and apoptosis in kidney and liver tissues of septic mice

X Zhao, S Zhang, H Shao - Bioengineered, 2022 - Taylor & Francis
Sepsis is capable of causing systemic infections resulting in multiple organ damage.
Dexpanthenol (DXP) has been reported to protect against kidney and liver injury. Therefore …

Protective effects of dexpanthenol in carbon tetrachloride-induced myocardial toxicity in rats

A Yildiz, T Demiralp, N Vardi, G Otlu, E Taslidere… - Tissue and Cell, 2022 - Elsevier
Exposure to various organic compounds including several environmental pollutants and
drugs can cause cellular damage through the generation of lipid peroxidation products …

Neuroprotective effects of dexpanthenol on rabbit spinal cord ischemia/reperfusion injury model

A Gülmez, PK Bektaşoğlu, Ç Tönge, A Yaprak… - World Neurosurgery, 2022 - Elsevier
Objective Dexpanthenol (DXP) reportedly protects tissues against oxidative damage in
various inflammation models. This study aimed to evaluate its effects on oxidative stress …

Dexpanthenol ameliorates doxorubicin-induced lung injury by regulating endoplasmic reticulum stress and apoptosis

MY Tepebaşı, Hİ Büyükbayram, Ö Özmen… - Naunyn-Schmiedeberg's …, 2023 - Springer
Doxorubicin (DOX), which is used as a chemotherapeutic agent in the treatment of tumors,
has limited use due to its toxicity in various organs and tissues. One of the organs where …

Alamandin and especially melatonin attenuate pulmonary arterial hypertension induced by monocrotalin

S Ayik, M Gunata, O Ozhan, A Yildiz… - Fundamental & …, 2024 - Wiley Online Library
Background Despite the available treatments, pulmonary arterial hypertension (PAH)
prognosis is poor. Objectives We aimed to investigate the effects of the alamandine (ALA) …

Fraxin in Combination with Dexamethasone Attenuates LPS‐Induced Liver and Heart Injury and Their Anticytokine Activity in Mice

NS Shaker, HB Sahib - Advances in Virology, 2023 - Wiley Online Library
Background. Cytokine storm syndrome (CSS) is a major cause of morbidity and mortality in
people suffering from hyperinflammatory status, which diverse etiological factors, including …

Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis …

FY Ding, JL Zhu, YL Hu - Acta Cirúrgica Brasileira, 2023 - SciELO Brasil
Purpose: Sepsis is characterized by an acute inflammatory response to infection, often with
multiple organ failures, especially severe lung injury. This study was implemented to probe …

The protective role of fosfomycin in lung injury due to oxidative stress and inflammation caused by sepsis

IE Yildiz, A Topcu, I Bahceci, M Arpa, L Tumkaya… - Life Sciences, 2021 - Elsevier
Aim Early and prompt treatment of sepsis by effective antibiotics against susceptible
organisms may be lifesaving. However, increased antibiotic resistance and side effects of …