Targeting galectin-driven regulatory circuits in cancer and fibrosis

KV Mariño, AJ Cagnoni, DO Croci… - Nature Reviews Drug …, 2023 - nature.com
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Roles of XBP1s in transcriptional regulation of target genes

SM Park, TI Kang, JS So - Biomedicines, 2021 - mdpi.com
The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …

High-throughput glycomic methods

I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

A review of alpha-1 antitrypsin binding partners for immune regulation and potential therapeutic application

ME O'Brien, G Murray, D Gogoi, A Yusuf… - International Journal of …, 2022 - mdpi.com
Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived
proteases and can modulate innate immune mechanisms through its anti-inflammatory …

Acute phase proteins as promising biomarkers: Perspectives and limitations for human and veterinary medicine

W Schrödl, R Büchler, S Wendler… - PROTEOMICS …, 2016 - Wiley Online Library
Acute phase proteins (APPs) are highly conserved plasma proteins that are increasingly
secreted by the liver in response to a variety of injuries, independently of their location and …

Plasma N-glycan signatures are associated with features of inflammatory bowel diseases

F Clerc, M Novokmet, V Dotz, KR Reiding, N de Haan… - Gastroenterology, 2018 - Elsevier
Background & Aims Biomarkers are needed for early detection of Crohn's disease (CD) and
ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and …

Gene expression profiling of the early pathogenesis of wooden breast disease in commercial broiler chickens using RNA-sequencing

MB Papah, EM Brannick, CJ Schmidt, B Abasht - PLoS One, 2018 - journals.plos.org
Wooden Breast Disease (WBD), a myopathy in commercial broiler chickens characterized
by abnormally firm consistency of the pectoral muscle, impacts the poultry industry …

Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

R Fuertes-Martín, X Correig, JC Vallvé… - Journal of clinical …, 2020 - mdpi.com
Several studies suggest that variations in the concentration of plasma glycoproteins can
influence cellular changes in a large number of diseases. In recent years, proton nuclear …

[HTML][HTML] Enhancing pharmacokinetic and pharmacodynamic properties of recombinant therapeutic proteins by manipulation of sialic acid content

S Chia, SJ Tay, Z Song, Y Yang, I Walsh… - Biomedicine & …, 2023 - Elsevier
The circulatory half-life of recombinant therapeutic proteins is an important pharmacokinetic
attribute because it determines the dosing frequency of these drugs, translating directly to …

Corticosteroid-binding globulin: a review of basic and clinical advances

EJ Meyer, MA Nenke, W Rankin… - Hormone and …, 2016 - thieme-connect.com
Corticosteroid-binding globulin (CBG, transcortin) is the primary cortisol binding protein. It is
a non-inhibitory serine protease inhibitor, capable of conformational change from a high …