Canonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as
major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the …

Epigenotoxicology is an emerging field of study that investigates the non-genotoxic
epigenetic effects of environmental toxicants resulting in alteration of normal gene …

A defining feature of early embryogenesis is the transition from maternal to zygotic control.
This transition requires embryo-wide zygotic genome activation (ZGA), but the extent of …

Mammalian oocytes and zygotes have the unique ability to reprogram a somatic cell nucleus
into a totipotent state. SUV 39H1/2‐mediated histone H3 lysine‐9 trimethylation (H3K9me3) …

As development proceeds, inductive cues are interpreted by competent tissues in a spatially
and temporally restricted manner. While key inductive signaling pathways within competent …

Transposable elements are parasitic genomic elements that can be deleterious for host
gene function and genome integrity. Heterochromatic histone modifications are involved in …

Recent advances in genome editing using programmable nucleases have revolutionized
gene targeting in various organisms. Successful gene knock-out has been shown in …

Dopamine homeostasis and oxidative stress are thought to be key players in the etiology of
Parkinson's disease (PD). PD is a disorder characterized by the death of dopaminergic …