Pyrrole, a simple heterocyclic system, is an important building block for numerous
biologically active compounds both natural and synthetic in origin, which boast an immense …

As a privileged class of heterocyclic compounds N-heteroarenes have found enormous
applications in many areas including medicinal/pharmaceutical chemistry and drug …

Abstract The 4-substituted pyrrolo [1, 2-a] quinoxaline framework was explored for the
identification of possible inhibitors of SIRT1. To access the target compounds a general and …

Nucleophilic aromatic substitution (SNAr) is a class of reaction that has become very
important over time. This type of transformation usually proceeds without the use of metal …

The direct synthesis of isoquinolones from benzamides and alkynes through C H activation
was developed by using Pd/C as a heterogeneous catalyst without a ligand under mild …

Pyrrolo [2, 3-b] quinoxaline derivatives are known to possess antioxidant, anticancer, and
antibacterial properties. Here we report the successful synthesis of five derivatives of 3 …

A transition metal free tandem two-step strategy has been developed involving hydrolysis of
2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the …

The regioselective synthesis of 1-alkyl-2-aryl-3-acyl pyrrolo [2, 3-b] quinoxalines through
palladium-catalyzed Heck coupling reaction/heteroannulation was reported. The reaction of …

A series of 1, 3-disubstituted pyrrolo [2, 3-b] quinoxalines has been designed for the
potential inhibition of PDE4 without inhibiting luciferase. A ligand/PTC (phase transfer …

The importance of the quinoxaline framework is exemplified by its presence in the well-
known drugs such as varenicline, brimonidine, quinacillin, etc. In the past few years …