[HTML][HTML] Ischemia/reperfusion

T Kalogeris, CP Baines, M Krenz… - Comprehensive …, 2016 - ncbi.nlm.nih.gov
Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Cell biology of ischemia/reperfusion injury

T Kalogeris, CP Baines, M Krenz, RJ Korthuis - International review of cell …, 2012 - Elsevier
Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of …

Immunoproteasomes: structure, function, and antigen presentation

DA Ferrington, DS Gregerson - Progress in molecular biology and …, 2012 - Elsevier
Immunoproteasomes contain replacements for the three catalytic subunits of standard
proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that …

Analysis of proteome dynamics in the mouse brain

JC Price, S Guan, A Burlingame… - Proceedings of the …, 2010 - National Acad Sciences
Advances in systems biology have allowed for global analyses of mRNA and protein
expression, but large-scale studies of protein dynamics and turnover have not been …

Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules

B Guillaume, J Chapiro, V Stroobant… - Proceedings of the …, 2010 - National Acad Sciences
Most antigenic peptides presented by MHC class I molecules result from the degradation of
intracellular proteins by the proteasome. In lymphoid tissues and cells exposed to IFNγ, the …

The ubiquitin-proteasome system in neurodegeneration

C McKinnon, SJ Tabrizi - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: Impairment of the ubiquitin-proteasome system (UPS) has been implicated in
the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's …

Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis

N Schmidt, E Gonzalez, A Visekruna, AA Kühl… - Gut, 2010 - gut.bmj.com
Background and aims Inflammatory bowel disease (IBD), comprising Crohn´ s disease and
ulcerative colitis, is characterised by chronic relapsing inflammation of the gut. Increased …

Proteasome inhibitors as experimental therapeutics of autoimmune diseases

SE Verbrugge, RJ Scheper, WF Lems… - Arthritis research & …, 2015 - Springer
Current treatment strategies for rheumatoid arthritis (RA) consisting of disease-modifying
anti-rheumatic drugs or biological agents are not always effective, hence driving the demand …

Mammalian proteasome subtypes: Their diversity in structure and function

B Dahlmann - Archives of biochemistry and biophysics, 2016 - Elsevier
The 20S proteasome is a multicatalytic proteinase catalysing the degradation of the majority
of intracellular proteins. Thereby it is involved in almost all basic cellular processes, which is …

[HTML][HTML] The ubiquitin–proteasome system in cardiac dysfunction

G Mearini, S Schlossarek, MS Willis, L Carrier - Biochimica et Biophysica …, 2008 - Elsevier
Since proteins play crucial roles in all biological processes, the finely tuned equilibrium
between their synthesis and degradation regulates cellular homeostasis. Controlling the …