The keloid disorder: heterogeneity, histopathology, mechanisms and models

GC Limandjaja, FB Niessen, RJ Scheper… - Frontiers in cell and …, 2020 - frontiersin.org
Keloids constitute an abnormal fibroproliferative wound healing response in which raised
scar tissue grows excessively and invasively beyond the original wound borders. This …

Wound healing: an overview

II George Broughton, JE Janis… - Plastic and reconstructive …, 2006 - journals.lww.com
Understanding wound healing today involves much more than simply stating that there are
three phases: inflammation, proliferation, and maturation. Wound healing is a complex …

Understanding keloid pathobiology from a quasi-neoplastic perspective: less of a scar and more of a chronic inflammatory disease with cancer-like tendencies

S Tan, N Khumalo, A Bayat - Frontiers in immunology, 2019 - frontiersin.org
Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of
the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids …

Overview of surgical scar prevention and management

D Son, A Harijan - Journal of Korean medical science, 2014 - synapse.koreamed.org
Management of incisional scar is intimately connected to stages of wound healing. The
management of an elective surgery patient begins with a thorough informed consent …

Hypoxia in tissue repair and fibrosis

IA Darby, TD Hewitson - Cell and tissue research, 2016 - Springer
Hypoxia and hypoxia signalling through the transcription factor hypoxia inducible factor-1
(HIF-1), play an important role in normal tissue repair processes. Tissue injury generally …

Molecular dissection of abnormal wound healing processes resulting in keloid disease

B Shih, E Garside, DA McGrouther… - Wound repair and …, 2010 - Wiley Online Library
Keloids are locally aggressive scars that typically invade into healthy surrounding skin and
cause both physical and psychosocial distress to the patient. These pathological scars occur …

[HTML][HTML] Altered glucose metabolism and cell function in keloid fibroblasts under hypoxia

Q Wang, P Wang, Z Qin, X Yang, B Pan, F Nie, H Bi - Redox biology, 2021 - Elsevier
Keloids exhibit metabolic reprogramming including enhanced glycolysis and attenuated
oxidative phosphorylation. Hypoxia induces a series of protective responses in mammalian …

Genetics of keloid scarring

B Shih, A Bayat - Archives of dermatological research, 2010 - Springer
Keloid scarring, also known as keloid disease (KD), is a common, abnormally raised
fibroproliferative cutaneous lesion that can occur following even minor skin trauma. The …

Current progress in keloid research and treatment

PD Butler, MT Longaker, GP Yang - Journal of the American …, 2008 - journals.lww.com
Keloids represent a form of pathologic wound healing affecting a substantial segment of the
US population. They are more common among African-American, Asian-American, Latin …

Insights into the pathophysiology of hypertrophic scars and keloids: how do they differ?

FM Ghazawi, R Zargham, MS Gilardino… - Advances in skin & …, 2018 - journals.lww.com
Hypertrophic scars and keloids are firm, raised, erythematous plaques or nodules that
manifest when the cicatrix fails to properly heal. They result from pathologic wound healing …