RNA in extracellular vesicles
Cells release a range of membrane‐enclosed extracellular vesicles (EVs) into the
environment. Among them, exosomes and microvesicles (collectively measuring 40–1000 …
environment. Among them, exosomes and microvesicles (collectively measuring 40–1000 …
MicroRNA: function, detection, and bioanalysis
Mature microRNAs (miRNAs) are a class of evolutionally conserved, single-stranded, small
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …
(approximately 19− 23 nucleotides), endogenously expressed, and non-protein-coding …
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA–an ISEV position paper
The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …
been demonstrated in a multitude of different in vitro cell systems and in a variety of body …
Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro
The delivery of therapeutics to the central nervous system remains a major challenge in part
due to the presence of the blood–brain barrier (BBB). Recently, cell-derived vesicles …
due to the presence of the blood–brain barrier (BBB). Recently, cell-derived vesicles …
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
Accurate spatiotemporal assessment of extracellular vesicle (EV) delivery and cargo RNA
translation requires specific and robust live-cell imaging technologies. Here we engineer …
translation requires specific and robust live-cell imaging technologies. Here we engineer …
Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate
MP Hall, J Unch, BF Binkowski, MP Valley… - ACS chemical …, 2012 - ACS Publications
Bioluminescence methodologies have been extraordinarily useful due to their high
sensitivity, broad dynamic range, and operational simplicity. These capabilities have been …
sensitivity, broad dynamic range, and operational simplicity. These capabilities have been …
Differential fates of biomolecules delivered to target cells via extracellular vesicles
M Kanada, MH Bachmann, JW Hardy… - Proceedings of the …, 2015 - National Acad Sciences
Extracellular vesicles (EVs), specifically exosomes and microvesicles (MVs), are presumed
to play key roles in cell–cell communication via transfer of biomolecules between cells. The …
to play key roles in cell–cell communication via transfer of biomolecules between cells. The …
A molecular imaging primer: modalities, imaging agents, and applications
ML James, SS Gambhir - Physiological reviews, 2012 - journals.physiology.org
Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …
Isolation and analysis methods of extracellular vesicles (EVs)
Extracellular vesicles (EVs) have been recognized as an evolving biomarker within the
liquid biopsy family. While carrying both host cell proteins and different types of RNAs, EVs …
liquid biopsy family. While carrying both host cell proteins and different types of RNAs, EVs …
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and
angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain …
angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain …