Inner ear supporting cells: rethinking the silent majority
Sensory epithelia of the inner ear contain two major cell types: hair cells and supporting
cells. It has been clear for a long time that hair cells play critical roles in mechanoreception …
cells. It has been clear for a long time that hair cells play critical roles in mechanoreception …
Inflammation associated with noise-induced hearing loss
MD Frye, AF Ryan, A Kurabi - The Journal of the Acoustical Society of …, 2019 - pubs.aip.org
Inflammation is a complex biological response to harmful stimuli including infection, tissue
damage, and toxins. Thus, it is not surprising that cochlear damage by noise includes an …
damage, and toxins. Thus, it is not surprising that cochlear damage by noise includes an …
Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma
K Hirose, CM Discolo, JR Keasler… - Journal of …, 2005 - Wiley Online Library
Acoustic injury results in destruction of hair cells and numerous nonsensory cells of the
cochlea. How these injured structures undergo repair is not well understood. This study was …
cochlea. How these injured structures undergo repair is not well understood. This study was …
[HTML][HTML] The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells
Cells of the immune system are present in the adult cochlea and respond to damage caused
by noise exposure. However, the types of immune cells involved and their locations within …
by noise exposure. However, the types of immune cells involved and their locations within …
Fractalkine signaling regulates macrophage recruitment into the cochlea and promotes the survival of spiral ganglion neurons after selective hair cell lesion
Macrophages are recruited into the cochlea in response to injury caused by acoustic trauma
or ototoxicity, but the nature of the interaction between macrophages and the sensory …
or ototoxicity, but the nature of the interaction between macrophages and the sensory …
[HTML][HTML] The contribution of immune infiltrates to ototoxicity and cochlear hair cell loss
MB Wood, J Zuo - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Cells of the immune system have been shown to infiltrate the cochlea after acoustic trauma
or ototoxic drug treatment; however, the contribution of the immune system to hair cell loss in …
or ototoxic drug treatment; however, the contribution of the immune system to hair cell loss in …
[HTML][HTML] Inflammatory and immune responses in the cochlea: potential therapeutic targets for sensorineural hearing loss
The inner ear was previously assumed to be an “immune-privileged” organ due to the
existence of its tight junction-based blood-labyrinth barrier. However, studies performed …
existence of its tight junction-based blood-labyrinth barrier. However, studies performed …
[HTML][HTML] The caspase pathway in noise-induced apoptosis of the chinchilla cochlea
TM Nicotera, BH Hu, D Henderson - … of the Association for Research in …, 2003 - Springer
We previously reported that intense noise exposure causes outer hair cell (OHC) death
primarily through apoptosis. Here we investigated the intracellular signal pathways …
primarily through apoptosis. Here we investigated the intracellular signal pathways …
[HTML][HTML] Macrophages in the human cochlea: saviors or predators—a study using super-resolution immunohistochemistry
W Liu, M Molnar, C Garnham, H Benav… - Frontiers in …, 2018 - frontiersin.org
The human inner ear, which is segregated by a blood/labyrinth barrier, contains resident
macrophages [CD163, ionized calcium-binding adaptor molecule 1 (IBA1)-, and CD68 …
macrophages [CD163, ionized calcium-binding adaptor molecule 1 (IBA1)-, and CD68 …
Immune cells and non-immune cells with immune function in mammalian cochleae
The cochlea has an immune environment dominated by macrophages under resting
conditions. When stressed, circulating monocytes enter the cochlea. These immune …
conditions. When stressed, circulating monocytes enter the cochlea. These immune …