In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Significance: Cytochrome bd is a ubiquinol: oxygen oxidoreductase of many prokaryotic
respiratory chains with a unique structure and functional characteristics. Its primary role is to …

Tuberculosis (TB), caused by bacilli from the Mycobacterium tuberculosis complex, remains
a serious global public health problem, representing one of the main causes of death from …

Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that predominantly affects
the alveolar macrophages in the respiratory tract. Upon infection, the activation of TLR2 and …

We are far away from the days when tuberculosis (TB) accounted for 1 in 4 deaths during the
19th century. However, Mycobacterium tuberculosis complex (MTBC) strains are still the …

New drugs with new mechanisms of action are urgently required to tackle the global
tuberculosis epidemic. Following the FDA-approval of the ATP synthase inhibitor …

The branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a
highly promising target for next-generation antibacterials. This system includes two terminal …

Methionine and cysteine metabolisms are important for the survival and pathogenesis of
Mycobacterium tuberculosis (Mtb). The transsulfuration pathway converts methionine to …

Mycobacterium tuberculosis can survive within its host for extended periods of time without
any clinical symptoms of disease and reactivate when the immune system is weakened. A …

Tuberculosis (TB) is still the leading global cause of death from an infectious bacterial agent.
Limiting tuberculosis epidemic spread is therefore an urgent global public health priority. As …