Chemistry, structure and function of approved oligonucleotide therapeutics
M Egli, M Manoharan - Nucleic Acids Research, 2023 - academic.oup.com
Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …
microRNAs in action: biogenesis, function and regulation
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …
years ago, a broad community of researchers was drawn to investigate the universe of small …
Bacterial origins of human cell-autonomous innate immune mechanisms
The cell-autonomous innate immune system enables animal cells to resist viral infection.
This system comprises an array of sensors that, after detecting viral molecules, activate the …
This system comprises an array of sensors that, after detecting viral molecules, activate the …
RNAi-based therapeutics and tumor targeted delivery in cancer
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …
for the development of targeted therapies for cancer and other diseases. The discovery of …
miRNA interplay: mechanisms and consequences in cancer
M Hill, N Tran - Disease models & mechanisms, 2021 - journals.biologists.com
Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown
that miRNAs are also capable of targeting non-coding RNAs, including long non-coding …
that miRNAs are also capable of targeting non-coding RNAs, including long non-coding …
RNA drugs and RNA targets for small molecules: principles, progress, and challenges
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
Nanozymes: classification, catalytic mechanisms, activity regulation, and applications
Y Huang, J Ren, X Qu - Chemical reviews, 2019 - ACS Publications
Because of the high catalytic activities and substrate specificity, natural enzymes have been
widely used in industrial, medical, and biological fields, etc. Although promising, they often …
widely used in industrial, medical, and biological fields, etc. Although promising, they often …
The current state and future directions of RNAi-based therapeutics
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
Regulation of microRNA function in animals
LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …
key regulators of biological processes in animals. These small RNAs form complex networks …