The correct duplication and transmission of genetic material to daughter cells is the primary
objective of the cell division cycle. DNA replication and chromosome segregation present …

Abstract The Replication Protein A (RPA) complex is an essential regulator of eukaryotic
DNA metabolism. RPA avidly binds to single-stranded DNA (ssDNA) through multiple …

RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability
and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is …

Mitotic DNA synthesis (MiDAS) is an unusual form of DNA replication that occurs during
mitosis. Initially, MiDAS was characterized as a process associated with intrinsically …

Replication protein A (RPA), the major single‐stranded DNA‐binding protein in eukaryotic
cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in …

Processing of DNA in replication, repair and recombination pathways in cells of all
organisms requires the participation of at least one major single-stranded DNA (ssDNA) …

Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …

The heterotrimeric eukaryotic Replication protein A (RPA) is a master regulator of numerous
DNA metabolic processes. For a long time, it has been viewed as an inert protector of …

DNA damage encountered by DNA replication forks poses risks of genome destabilization, a
precursor to carcinogenesis. Damage checkpoint systems cause cell cycle arrest, promote …

Human replication protein A (RPA), a heterotrimeric protein complex, was originally defined
as a eukaryotic single‐stranded DNA binding (SSB) protein essential for the in vitro …