Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …

Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and
are increasingly used to track organisms along their life-course. This allows investigation …

Sample multiplexing facilitates scRNA-seq by reducing costs and identifying artifacts such
as cell doublets. However, universal and scalable sample barcoding strategies have not …

Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based
functional studies in T cells could prioritize novel targets for drug development and improve …

Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically,
senescence also induces an inflammatory secretome that promotes carcinogenesis and age …

A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular
senescence affects normal aging and age-related disease. Mitogen-activated protein …

Senescent cells activate genetic programmes that irreversibly inhibit cellular proliferation,
but also endow these cells with distinctive metabolic and signalling phenotypes. Although …

Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …

Senescence is a stable growth arrest that impairs the replication of damaged, old or
preneoplastic cells, therefore contributing to tissue homeostasis. Senescent cells …

The growing scale and declining cost of single-cell RNA-sequencing (RNA-seq) now permit
a repetition of cell sampling that increases the power to detect rare cell states, reconstruct …