S100B in brain damage and neurodegeneration

M Rothermundt, M Peters, JHM Prehn… - … research and technique, 2003 - Wiley Online Library
S100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …

Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics

E Kövesdi, J Lückl, P Bukovics, O Farkas, J Pál… - Acta …, 2010 - Springer
Purpose This review summarizes protein biomarkers in mild and severe traumatic brain
injury in adults and children and presents a strategy for conducting rationally designed …

S100B protein in biological fluids: a tool for perinatal medicine

F Michetti, D Gazzolo - Clinical Chemistry, 2002 - academic.oup.com
The diagnosis of perinatal insults currently relies on adequate documentation of general
medical and obstetric factors and on radiologic and laboratory assessments. The …

A critical analysis of the role of the neurotrophic protein S100B in acute brain injury

A Kleindienst, MR Bullock - Journal of neurotrauma, 2006 - liebertpub.com
We provide a critical analysis of the relevance of S100B in acute brain injury emphazising
the beneficial effect of its biological properties. S100B is a calcium-binding protein, primarily …

The phosphorylated axonal form of the neurofilament subunit NF-H (pNF-H) as a blood biomarker of traumatic brain injury

KJ Anderson, SW Scheff, KM Miller… - Journal of …, 2008 - liebertpub.com
The detection of neuron-specific proteins in blood might allow quantification of the degree of
neuropathology in experimental and clinical contexts. We have been studying a novel blood …

The neurotrophic protein S100B: value as a marker of brain damage and possible therapeutic implications

A Kleindienst, F Hesse, MR Bullock… - Progress in brain …, 2007 - Elsevier
We provide a critical analysis of the value of S100B as a marker of brain damage and
possible therapeutic implications. The early assessment of the injury severity and the …

Cleaved-tau: a biomarker of neuronal damage after traumatic brain injury

SP Gabbita, SW Scheff, RM Menard… - Journal of …, 2005 - liebertpub.com
Previous studies from our laboratory indicate that traumatic brain injury (TBI) in humans
results in proteolysis of neuronally-localized, intracellular microtubule associated protein …

Serum S 100 B: a marker of brain damage in traumatic brain injury with and without multiple trauma

LE Pelinka, E Toegel, W Mauritz, H Redl - Shock, 2003 - journals.lww.com
This prospective clinical study was conducted to determine whether S 100 B is a reliable
serum marker for traumatic brain injury (TBI) with and without multiple trauma. Fifty-five …

Traumatic white matter injury and glial activation: from basic science to clinics

Z Kou, PJ VandeVord - Glia, 2014 - Wiley Online Library
An improved understanding and characterization of glial activation and its relationship with
white matter injury will likely serve as a novel treatment target to curb post injury …

Serum-based protein biomarkers in blast-induced traumatic brain injury spectrum disorder

DV Agoston, M Elsayed - Frontiers in neurology, 2012 - frontiersin.org
The biological consequences of exposure to explosive blast are extremely complex. Serum
protein biomarkers in blast-induced traumatic brain injury (bTBI) can aid in determining …