Aldosterone is a major mineralocorticoid steroid hormone secreted by glomerulosa cells in
the adrenal cortex. It regulates a variety of physiological responses including those to …

Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the
three IC subtypes identified, type B intercalated cells are one of the best characterized and …

The progression of diabetic kidney disease (DKD), a leading cause of end-stage kidney
disease, involves mineralocorticoid receptor (MR) activation. We previously identified …

The currently available data have indicated that dietary salt is directly correlated with blood
pressure (BP) and the occurrence of hypertension. However, the salt sensitivity of BP is …

Regulation and action of the mineralocorticoid receptor (MR) have been the focus of
intensive research over the past 80 years. Genetic and physiological/biochemical analysis …

Hypertension and its comorbidities pose a major public health problem associated with
disease-associated factors related to a modern lifestyle, such high salt intake or obesity …

The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-
intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells …

The epithelium of the kidney collecting duct (CD) is composed mainly of two different types
of cells with distinct and complementary functions. CD principal cells traditionally have been …

Sodium glucose cotransporter 2 (SGLT2) inhibitors have both glucose-lowering and diuretic
effects. We recently reported that the SGLT2 inhibitor dapagliflozin exerts short-term fluid …

Pendrin is a Cl−/HCO3− exchanger selectively present in the intercalated cells of the kidney.
Although experimental studies have demonstrated that pendrin regulates blood pressure …