Abstract Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …

The biochemical role of the PI3K/PKB/mTOR signalling pathway in cell-cycle regulation is
now well known. During the onset and development of different forms of cancer it becomes …

PURPOSE Phosphatidylinositol-3-kinase (PI3K) inhibitors have shown activity in relapsed or
refractory (R/R) indolent non-Hodgkin lymphoma (iNHL). PI3K inhibitors have been …

Immunotherapy has led to a paradigm shift in the treatment of cancer. Current cancer
immunotherapies are mostly antibody-based, thus possessing advantages in regard to …

Abstract The phosphatidylinositol 3-kinase (PI3K) signalling pathway regulates cell survival,
proliferation, migration, metabolism and other vital cellular life processes. In addition …

Pyrazole is a five-membered heterocycle bearing two adjacent nitrogen atoms. Both
pharmaceutical agents and natural products with pyrazole as a nucleus have exhibited a …

The tumor microenvironment (TME) plays an essential role in the development, growth, and
survival of the malignant B-cell clone in chronic lymphocytic leukemia (CLL). Within the …

Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes
and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway …

Simple Summary The development of small agents targeting the B-cell receptor (BCR)
pathway revolutionized the treatment of chronic lymphocytic leukemia (CLL). BCR …

The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven
CK1 isoforms identified in humans. The most important substrates of CK1 kinases are …