Chagas disease is a chronic, systemic, parasitic infection caused by the protozoan
Trypanosoma cruzi, and was discovered in 1909. The disease affects about 8 million people …

Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America
and affects ca. 10 million people worldwide. About 30% of Chagas disease patients develop …

Glycosylphosphatidylinositol (GPI) anchors and glycoinositolphospholipids (GIPLs) from
parasitic protozoa have been shown to exert a wide variety of effects on cells of the host …

Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …

Interferon (IFN)-α/β and interleukin (IL)-12 are cytokines critical in defense against viruses,
but their cellular sources and mechanisms of regulation for in vivo expression remain poorly …

Macrophage-derived radicals generated by the NADPH oxidase complex and inducible
nitric-oxide synthase (iNOS) participate in cytotoxic mechanisms against microorganisms …

Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is
characterised by a variable clinical course–from symptomless cases to severe chronic …

Background—The pathogenesis of myocarditis that occurs in Trypanosoma cruzi–infected
mice is still poorly understood. Therefore, it is important to know the mediators that trigger …

WSX-1 is a class I cytokine receptor with homology to the IL-12 receptors and is essential for
resistance to Leishmania major infection. In the present study, we demonstrated that WSX-1 …

Trypanosoma cruzi, the causative agent of Chagas' disease, induces an innate and adaptive
host immune response during the acute phase of infection. These responses were analyzed …