[PDF][PDF] Geroscience and pathology: a new frontier in understanding age-related diseases
M Fekete, D Major, A Feher… - Pathology and …, 2024 - por-journal.com
Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …
understand the relationship between the aging process and pathogenesis of age-related …
[HTML][HTML] Breast cancer chemoresistance: Insights into the regulatory role of lncRNA
ST Ahmadpour, C Orre, PS Bertevello… - International journal of …, 2023 - mdpi.com
Long noncoding RNAs (lncRNAs) are a subclass of noncoding RNAs composed of more
than 200 nucleotides without the ability to encode functional proteins. Given their …
than 200 nucleotides without the ability to encode functional proteins. Given their …
GBP2 enhances paclitaxel sensitivity in triple‑negative breast cancer by promoting autophagy in combination with ATG2 and inhibiting the PI3K/AKT/mTOR pathway
W Zhang, X Tang, Y Peng, Y Xu… - … journal of oncology, 2024 - spandidos-publications.com
Chemoresistance is a major challenge in treating triple‑negative breast cancer (TNBC);
chemotherapy remains the primary approach. The present study aimed to elucidate the role …
chemotherapy remains the primary approach. The present study aimed to elucidate the role …
[HTML][HTML] Jatrophone: a cytotoxic macrocylic diterpene targeting PI3K/AKT/NF-κB pathway, inducing apoptosis and autophagy in resistant breast cancer cells
K Shari, RA El Gedaily, RM Allam, KM Meselhy… - … Medicine and Therapies, 2023 - Springer
Background Breast cancer is a prevalent malignant tumor that affects women worldwide.
The primary challenge in treating breast cancer is combating drug resistance, which …
The primary challenge in treating breast cancer is combating drug resistance, which …
Iron-chelated and GSH-responsive polymersome nanoreactors facilitating therapeutic cascade reactions in cooperative starvation-ferroptosis therapy
A combination of starvation therapy and ferroptosis offers a potent therapeutic strategy to
treat triple-negative breast cancer (TNBC). Herein, a polymersome-based nanoreactor …
treat triple-negative breast cancer (TNBC). Herein, a polymersome-based nanoreactor …
[HTML][HTML] MicroRNA-183 cluster: a promising biomarker and therapeutic target in gastrointestinal malignancies
Y Zheng, O Sukocheva, E Tse… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Small non-coding RNAs (microRNA, miR), powerful epigenetic regulators, were found
involved in the regulation of most biological functions via post-translational inhibition of …
involved in the regulation of most biological functions via post-translational inhibition of …
The potential therapeutic effect of melatonin in oxaliplatin combination therapy against chemoresistant colorectal cancer cells
M Dehghanzad, M Mohammadi, M Nejati… - Molecular Biology …, 2024 - Springer
Background Oxaliplatin is one of the main therapeutics in colorectal cancer (CRC)
chemotherapy. However, in light of multidrug resistance (MDR) phenotype development, the …
chemotherapy. However, in light of multidrug resistance (MDR) phenotype development, the …
Rapamycin inhibits B16 melanoma cell viability in vitro and in vivo by inducing autophagy and inhibiting the mTOR/p70‑S6k pathway
P Wang, H Zhang, K Guo, C Liu, S Chen… - Oncology …, 2024 - spandidos-publications.com
Rapamycin is an immunosuppressant that has been shown to prevent tumor growth
following organ transplantation. However, its exact mode of antitumor action remains …
following organ transplantation. However, its exact mode of antitumor action remains …
Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective
S Raza, JA Siddiqui, A Srivastava… - Autophagy …, 2024 - Taylor & Francis
Breast cancer is a heterogeneous disease, with a subpopulation of tumor cells known as
breast cancer stem cells (BCSCs) with self-renewal and differentiation abilities that play a …
breast cancer stem cells (BCSCs) with self-renewal and differentiation abilities that play a …
[HTML][HTML] Integrated network pharmacology, bioinformatics, and molecular docking to explore the mechanisms of berberine regulating autophagy in breast cancer
B Huang, G Wen, R Li, M Wu, Z Zou - Medicine, 2023 - journals.lww.com
Berberine exhibits anticancer efficacy against a variety of malignancies, including breast
cancer (BRCA). However, the underlying mechanism is ambiguous. This study sought to …
cancer (BRCA). However, the underlying mechanism is ambiguous. This study sought to …