The role of aberrations in the immune-inflammatory response system (IRS) and the compensatory immune-regulatory reflex system (CIRS) in different phenotypes of …

C Roomruangwong, C Noto, B Kanchanatawan… - Molecular …, 2020 - Springer
Several lines of evidence indicate that aberrations in immune-inflammatory pathways may
contribute to the pathophysiology of schizophrenia spectrum disorders. Here, we propose a …

[HTML][HTML] Cardiovascular and metabolic protection by vitamin E: A matter of treatment strategy?

M Ziegler, M Wallert, S Lorkowski, K Peter - Antioxidants, 2020 - mdpi.com
Cardiovascular diseases (CVD) cause about 1/3 of global deaths. Therefore, new strategies
for the prevention and treatment of cardiovascular events are highly sought-after. Vitamin E …

Upregulation of the intestinal paracellular pathway with breakdown of tight and adherens junctions in deficit schizophrenia

M Maes, S Sirivichayakul, B Kanchanatawan… - Molecular …, 2019 - Springer
In 2001, the first author of this paper reported that schizophrenia is associated with an
increased frequency of the haptoglobin (Hp)-2 gene. The precursor of Hp-2 is zonulin, a …

The role of micronutrients in ageing Asia: what can be implemented with the existing insights

T Inui, B Hanley, ES Tee, J Nishihira, K Tontisirin… - Nutrients, 2021 - mdpi.com
Life expectancy as a measure of population health does not reflect years of healthy life. The
average life expectancy in the Asia-Pacific region has more than doubled since 1900 and is …

Unique contribution of haptoglobin and haptoglobin genotype in aneurysmal subarachnoid hemorrhage

SL Blackburn, PT Kumar, D McBride… - Frontiers in …, 2018 - frontiersin.org
Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological
deficits. Much of this is related to the effects of blood in the subarachnoid space which …

Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients

S Wang, J Wang, R Zhang, T Wang, D Yan… - Cardiovascular …, 2018 - Springer
Abstract Background Haptoglobin (Hp) functions as an antioxidant by binding with
haemoglobin. We investigated whether serum Hp has a causal effect on macroangiopathy …

Influence of haptoglobin polymorphism on stroke in sickle cell disease patients

O Edwards, A Burris, J Lua, DJ Wilkie, MO Ezenwa… - Genes, 2022 - mdpi.com
This review outlines the current clinical research investigating how the haptoglobin (Hp)
genetic polymorphism and stroke occurrence are implicated in sickle cell disease (SCD) …

Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians

RL Gurung, R Dorajoo, S Liu, JJ Liu, L Wang, L Guo… - Scientific Reports, 2018 - nature.com
Urine haptoglobin (uHP) level prospectively predicts diabetic kidney disease (DKD)
progression. Here, we aim to identify genetic determinants of uHP level and evaluate …

IL‐6 induces haptoglobin expression through activating STAT3 in human head and neck cancer

SC Li, CC Lee, CM Hsu, HB Huang… - Journal of Oral …, 2020 - Wiley Online Library
Abstract Objective Haptoglobin (Hp) is an acute‐phase protein secreted by the liver; its
concentration increases rapidly during infection, inflammation, and tumor formation. It has …

Cardiovascular disease in adults with type 1 diabetes: looking beyond glycemic control

RG Miller, T Costacou - Current cardiology reports, 2022 - Springer
Abstract Purpose of Review Despite improvements in treatment, people with type 1 diabetes
continue to have increased cardiovascular disease (CVD) risk. Glycemic control does not …