Physical illness and schizophrenia: a review of the literature

S Leucht, T Burkard, J Henderson… - Acta Psychiatrica …, 2007 - Wiley Online Library
Objective: The lifespan of people with schizophrenia is shortened compared to the general
population. We reviewed the literature on comorbid physical diseases in schizophrenia to …

Cancer incidence in patients with schizophrenia and their first‐degree relatives–a meta‐analysis

VS Catts, SV Catts, BI O'toole… - Acta Psychiatrica …, 2008 - Wiley Online Library
Objective: Controversy concerning cancer incidence in schizophrenia exists because of
heterogeneous study findings. Method: A meta‐analysis was performed on standardized …

[HTML][HTML] Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care

M De Hert, CU Correll, J Bobes… - World …, 2011 - ncbi.nlm.nih.gov
The lifespan of people with severe mental illness (SMI) is shorter compared to the general
population. This excess mortality is mainly due to physical illness. We report prevalence …

[HTML][HTML] Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells

E Sachlos, RM Risueño, S Laronde, Z Shapovalova… - Cell, 2012 - cell.com
Selective targeting of cancer stem cells (CSCs) offers promise for a new generation of
therapeutics. However, assays for both human CSCs and normal stem cells that are …

Psychosis and autism as diametrical disorders of the social brain

B Crespi, C Badcock - Behavioral and brain sciences, 2008 - cambridge.org
Autistic-spectrum conditions and psychotic-spectrum conditions (mainly schizophrenia,
bipolar disorder, and major depression) represent two major suites of disorders of human …

Patterns of tobacco-related mortality among individuals diagnosed with schizophrenia, bipolar disorder, or depression

RC Callaghan, S Veldhuizen, T Jeysingh… - Journal of psychiatric …, 2014 - Elsevier
Even though individuals with psychiatric conditions have a prevalence of smoking
approximately 2–4 times greater than the general population, surprisingly little evidence …

[HTML][HTML] A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma

I Arrillaga-Romany, AS Chi, JE Allen, W Oster… - Oncotarget, 2017 - ncbi.nlm.nih.gov
ONC201 is an oral, small molecule selective antagonist of the G protein-coupled receptor
DRD2 that causes p53-independent apoptosis in tumor cells via integrated stress response …

Inverse and direct cancer comorbidity in people with central nervous system disorders: a meta-analysis of cancer incidence in 577,013 participants of 50 observational …

F Catalá-López, M Suárez-Pinilla… - Psychotherapy and …, 2014 - karger.com
Background: There is a lack of scientific consensus about cancer comorbidity in people with
central nervous system (CNS) disorders. This study assesses the co-occurrence of cancers …

Expression of DRD2 is increased in human pancreatic ductal adenocarcinoma and inhibitors slow tumor growth in mice

P Jandaghi, HS Najafabadi, AS Bauer, AI Papadakis… - Gastroenterology, 2016 - Elsevier
Background & Aims Incidence of and mortality from pancreatic ductal adenocarcinoma
(PDAC), the most common form of pancreatic cancer, are almost equivalent, so better …

Association of schizophrenia with the risk of breast cancer incidence: a meta-analysis

C Zhuo, PT Triplett - JAMA psychiatry, 2018 - jamanetwork.com
Importance Patients with schizophrenia are considered to have many risk factors for the
development of cancer. However, the incidence of breast cancer in women with …