Recent updates on 1, 2, 3‐, 1, 2, 4‐, and 1, 3, 5‐triazine hybrids (2017–present): The anticancer activity, structure–activity relationships, and mechanisms of action
G Dong, Y Jiang, F Zhang, F Zhu, J Liu… - Archiv der …, 2023 - Wiley Online Library
Cancer is one of the leading causes of death across the world, and the prevalence and
mortality rates of cancer will continue to grow. Chemotherapeutics play a critical role in …
mortality rates of cancer will continue to grow. Chemotherapeutics play a critical role in …
“Azole” as privileged heterocycle for targeting the inducible cyclooxygenase enzyme
An over‐expression of COX‐2 isoenzyme belonging to the Cyclooxygenase Enzyme Family
triggers the overproduction of pro‐inflammatory prostaglandins that instigate the …
triggers the overproduction of pro‐inflammatory prostaglandins that instigate the …
New 4-(2-Furyl)-1, 4-dihydronicotinonitriles and 1, 4, 5, 6-Tetrahydronicotinonitriles: synthesis, structure, and analgesic activity
DS Krivokolysko, VV Dotsenko, EY Bibik… - Russian Journal of …, 2021 - Springer
A series of new hybrid molecules containing 2-furyl and partially saturated pyridine
fragments was obtained based on the reaction of cyanothioacetamide with furfural and 1, 3 …
fragments was obtained based on the reaction of cyanothioacetamide with furfural and 1, 3 …
New hybrid molecules based on sulfur-containing nicotinonitriles: Synthesis, analgesic activity in acetic acid-induced writhing test, and molecular docking studies
DS Krivokolysko, VV Dotsenko, EY Bibik… - Russian Journal of …, 2022 - Springer
New hybrid molecules bearing furyl and 1, 4-dihydronicotinonitrile (or 1, 4, 5, 6-
tetrahydronicotinonitrile) fragments have been prepared. The analgesic activity was studied …
tetrahydronicotinonitrile) fragments have been prepared. The analgesic activity was studied …
New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico …
NP Novichikhina, AS Shestakov, SM Medvedeva… - Molecules, 2023 - mdpi.com
Despite extensive research in the field of thrombotic diseases, the prevention of blood clots
remains an important area of study. Therefore, the development of new anticoagulant drugs …
remains an important area of study. Therefore, the development of new anticoagulant drugs …
The emerging potential of SIRT-3 in oxidative stress-inflammatory axis associated increased neuroinflammatory component for metabolically impaired neural cell
A Alzahrani, MESM El-Daly, ALSHFF Ahmed - Chemico-Biological …, 2021 - Elsevier
People suffering from conditions like epilepsy, where there is an excess of neuron
excitement, stroke, and cardiac arrest, where there are oxygen and glucose deprivation …
excitement, stroke, and cardiac arrest, where there are oxygen and glucose deprivation …
Scalable Synthetic Strategy for Unsymmetrical Trisubstituted s-Triazines
H Liang, G Li, L Zhang, G Wang, M Song, H Li… - Organic …, 2021 - ACS Publications
A scalable synthetic strategy to produce a large variety of unsymmetrical trisubstituted 1, 3, 5-
triazines was developed. This protocol applied in situ formed acyl isocyanate from amide to …
triazines was developed. This protocol applied in situ formed acyl isocyanate from amide to …
Synthesis and in vitro study of cytotoxic activity of new tetrazole-containing 2, 4-diamino-1, 3, 5-triazine derivatives
OV Mikolaichuk, AV Protas, EA Popova… - Russian Journal of …, 2022 - Springer
New tetrazole-containing derivatives of 2, 4-diamino-1, 3, 5-triazine were synthesized. The
cytotoxic activity of the obtained compounds against Huh-7 and HeLa tumor cell lines was …
cytotoxic activity of the obtained compounds against Huh-7 and HeLa tumor cell lines was …
Boronate affinity/hydrophobic charge induction synergistic adsorption for improving purification of antibody
X Liu, J Niu, J Shen, H Chu, C Wang, Y Wei - Chemical Engineering …, 2024 - Elsevier
Adsorbents modified with small molecular ligands have shown great advantages in the
downstream purification of antibody, but they still face some challenges caused by single …
downstream purification of antibody, but they still face some challenges caused by single …
Synthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1, 4-dihydropyridin-3-yl} carboxamido) benzoic Acids Ethyl Esters
DS Krivokolysko, VV Dotsenko, EY Bibik… - Russian Journal of …, 2021 - Springer
A series of new hybrid molecules containing fragments of anestesin and 4-(2-furyl)-1, 4-
dihydronicotinonitrile have been obtained starting from diketene, ethyl 4-aminobenzoate …
dihydronicotinonitrile have been obtained starting from diketene, ethyl 4-aminobenzoate …