Traumatic optic neuropathy: a review of current studies

B Chen, H Zhang, Q Zhai, H Li, C Wang, Y Wang - Neurosurgical Review, 2022 - Springer
Traumatic optic neuropathy (TON) is a serious complication of craniofacial trauma that
directly or indirectly damages the optic nerve and can cause severe vision loss. The …

A systematic literature review on traumatic optic neuropathy

S Karimi, A Arabi, I Ansari, T Shahraki… - Journal of …, 2021 - Wiley Online Library
Traumatic optic neuropathy (TON) is an uncommon vision‐threatening disorder that can be
caused by ocular or head trauma and is categorized into direct and indirect TON. The overall …

Retinal neurodegeneration and brain MRI markers: the Rotterdam Study

U Mutlu, PWM Bonnemaijer, MA Ikram, JM Colijn… - Neurobiology of …, 2017 - Elsevier
We investigated the association of specific retinal sublayer thicknesses on optical coherence
tomography (OCT) with brain magnetic resonance imaging (MRI) markers. We included …

[HTML][HTML] Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathy

NK Evanson, F Guilhaume-Correa, JP Herman… - PLoS …, 2018 - journals.plos.org
Adult male C57BL/6J mice have previously been reported to have motor and memory
deficits after experimental closed head traumatic brain injury (TBI), without associated gross …

Traumatic optic neuropathy treatment trial (TONTT): open label, phase 3, multicenter, semi-experimental trial

MB Kashkouli, S Yousefi, M Nojomi, MS Sanjari… - Graefe's Archive for …, 2018 - Springer
Purpose Intravenously administered erythropoietin (EPO) was firstly commenced (phase 1)
in patients with indirect traumatic optic neuropathy (TON) by this group in 2011. It was re …

A novel mouse model of traumatic optic neuropathy using external ultrasound energy to achieve focal, indirect optic nerve injury

W Tao, G Dvoriantchikova, BC Tse, S Pappas… - Scientific reports, 2017 - nature.com
Traumatic optic neuropathy (TON) is a devastating cause of permanent visual loss following
blunt injury to the head. Animal models for TON exist, but most fail to recapitulate the clinical …

Traumatic optic neuropathy is associated with visual impairment, neurodegeneration, and endoplasmic reticulum stress in adolescent mice

SM Hetzer, F Guilhaume-Correa, D Day, A Bedolla… - Cells, 2021 - mdpi.com
Traumatic brain injury (TBI) results in a number of impairments, often including visual
symptoms. In some cases, visual impairments after head trauma are mediated by traumatic …

Exosome-mediated delivery of the neuroprotective peptide PACAP38 promotes retinal ganglion cell survival and axon regeneration in rats with traumatic optic …

T Wang, Y Li, M Guo, X Dong, M Liao, M Du… - Frontiers in cell and …, 2021 - frontiersin.org
Traumatic optic neuropathy (TON) refers to optic nerve damage caused by trauma, leading
to partial or complete loss of vision. The primary treatment options, such as hormonal …

[HTML][HTML] Indirect traumatic optic neuropathy in mild chronic traumatic brain injury

JW Chan, NK Hills, B Bakall… - … ophthalmology & visual …, 2019 - jov.arvojournals.org
Purpose: To analyze the clinical presentation and optical coherence tomography (OCT)
findings in indirect traumatic optic neuropathy (ITON) in veterans with chronic mild traumatic …

A hypothermia mimetic molecule (zr17-2) reduces ganglion cell death and electroretinogram distortion in a rat model of intraorbital optic nerve crush (IONC)

DS Contartese, M Rey-Funes, R Peláez… - Frontiers in …, 2023 - frontiersin.org
Introduction: Ocular and periocular traumatisms may result in loss of vision. Our previous
work showed that therapeutic hypothermia prevents retinal damage caused by traumatic …