A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …

During the past five years, copy number variation (CNV) has emerged as a highly prevalent
form of genomic variation, bridging the interval between long-recognised microscopic …

Hundreds of genes reside in structurally complex, poorly understood regions of the human
genome,,. One such region contains the three amylase genes (AMY2B, AMY2A and AMY1) …

The chemokine receptor CCR5 has been the focus of intensive studies since its role as a
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …

Chemokines play an important role in orchestrating cell recruitment and localization in both
physiological and pathological conditions. More than 44 ligands have been identified in the …

Understanding HIV remission in rare individuals who initiated antiretroviral therapy (ART)
soon after infection and then discontinued, may inform HIV cure interventions. Here we …

Physiological leukocyte homing and extravasation of leukocytes during inflammatory
processes is directed by a number of proteins including adhesion molecules, proteases …

Post-translational modification of chemokines is an essential regulatory mechanism to
enhance or dampen the inflammatory response. CD26/dipeptidylpeptidase IV, ubiquitously …

Copy number variation (CNV) in the human genome is an important determinant of
susceptibility to autoimmune diseases. Many autoimmune diseases share similar clinical …

Hundreds of copy number variants are complex and multi-allelic, in that they have many
structural alleles and have rearranged multiple times in the ancestors who contributed …