[HTML][HTML] Seventy years of Chlamydia vaccine research–limitations of the past and directions for the future

S Phillips, BL Quigley, P Timms - Frontiers in microbiology, 2019 - frontiersin.org
Chlamydia is a major bacterial pathogen that infects humans, as well as a wide range of
animals, including marsupials, birds, cats, pigs, cattle, and sheep. Antibiotics are the only …

Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research

S Vasilevsky, G Greub… - Clinical microbiology …, 2014 - Am Soc Microbiol
Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease
worldwide, and despite significant advances in chlamydial research, a prophylactic vaccine …

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

NPH Knudsen, A Olsen, C Buonsanti, F Follmann… - Scientific reports, 2016 - nature.com
The majority of vaccine candidates in clinical development are highly purified proteins and
peptides relying on adjuvants to enhance and/or direct immune responses. Despite the …

Development status and future prospects for a vaccine against Chlamydia trachomatis infection

LM Hafner, DP Wilson, P Timms - Vaccine, 2014 - Elsevier
Chlamydia trachomatis continues to be the most commonly reported sexually transmitted
bacterial infection in many countries with more than 100 million new cases estimated …

[HTML][HTML] Induction of partial immunity in both males and females is sufficient to protect females against sexual transmission of Chlamydia

CP O'Meara, CW Armitage, A Kollipara, DW Andrew… - Mucosal …, 2016 - Elsevier
Sexually transmitted Chlamydia trachomatis causes infertility, and because almost 90% of
infections are asymptomatic, a vaccine is required for its eradication. Mathematical modeling …

Prophylactic and therapeutic vaccination protects sperm health from Chlamydia muridarum-induced abnormalities

ER Bryan, LK Trim, P Sadowski… - Biology of …, 2023 - academic.oup.com
Chlamydia is the most common bacterial sexually transmitted infection worldwide and it is
widely acknowledged that controlling the rampant community transmission of this infection …

[HTML][HTML] Enhanced clearance of C. muridarum infection using azithromycin-loaded liposomes

Y Arasu, E Bryan, FA Russell, N Huettner… - International Journal of …, 2024 - Elsevier
Chlamydia trachomatis is an intracellular bacterium which infects around 129 million people
annually. Despite similar infection rates between sexes, most research investigating the …

Future of human Chlamydia vaccine: potential of self-adjuvanting biodegradable nanoparticles as safe vaccine delivery vehicles

R Sahu, R Verma, S Dixit, JU Igietseme… - Expert review of …, 2018 - Taylor & Francis
Introduction: There is a persisting global burden and considerable public health challenge
by the plethora of ocular, genital and respiratory diseases caused by members of the Gram …

Hematogenous dissemination of Chlamydia muridarum from the urethra in macrophages causes testicular infection and sperm DNA damage

ER Bryan, A Kollipara, LK Trim… - Biology of …, 2019 - academic.oup.com
The incidence of Chlamydia infection, in both females and males, is increasing worldwide.
Male infections have been associated clinically with urethritis, epididymitis, and orchitis …

Chronic testicular Chlamydia muridarum infection impairs mouse fertility and offspring development

ER Bryan, KA Redgrove, AR Mooney… - Biology of …, 2020 - academic.oup.com
With approximately 131 million new genital tract infections occurring each year, Chlamydia
is the most common sexually transmitted bacterial pathogen worldwide. Male and female …