The physiological roles of proteolysis are not limited to degrading unnecessary proteins.
Proteolysis plays pivotal roles in various biological processes through cleaving peptide …

The spontaneous autosomal recessive mouse mutation, Purkinje cell degeneration (pcd),
was first identified through its ataxic behavior. Since its discovery in the 1970s, the strain has …

Mitochondrial function, in particular complex 1 of the electron transport chain (ETC), has
been shown to decrease during normal ageing and in neurodegenerative disease …

Nnal is a recently described gene product that has sequence similarity with metallocar‐
boxypeptidases. In the present study, five additional Nnal‐like genes were identified in the …

Purkinje cells are a class of specialized neurons in the cerebellum, and are among the most
metabolically active of all neurons, as they receive immense synaptic stimulation, and …

One of the major challenges facing the long term survival of neurons is their requirement to
maintain efficient axonal transport over long distances. In humans as large, long-lived …

Abstract Approximately 10%–15% of couples worldwide are infertile, and male factors
account for approximately half of these cases. Teratozoospermia is a major cause of male …

Even though it is among the most commonly methylated loci in multiple cancers, the retinoic
acid–induced tumor suppressor retinoic acid receptor responder 1 (RARRES1) has no …

Haemoglobins are iron-containing proteins that transport oxygen in the blood of most
vertebrates. The mitochondrion is the cellular organelle which consumes oxygen in order to …

Many inherited visual diseases arise from mutations that affect the structure and function of
photoreceptor cells. In some cases, the pathology is accompanied by a massive release of …