Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

The inflammatory response involves the activation of several cell types to fight insults
caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand …

Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

The tricarboxylic acid cycle (TCA cycle) has been known for decades as a hub for
generating cellular energy and precursors for biosynthetic pathways. Several cancers …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …