The insulin-like peptide (ILP) and insulin-like growth factor (IGF) signalling pathways play a
crucial role in the regulation of metabolism, growth and development, fecundity, stress …

Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus
countering apoptosis, beta-amyloid toxicity, and oxidative stress; favoring neuronal survival; …

The rigorous balance of endocrine signals that control insect reproductive physiology is
crucial for the success of egg production. Rhodnius prolixus, a blood-feeding insect and …

Nutrition‐dependent growth of sexual traits is a major contributor to phenotypic diversity, and
a large body of research documents insulin signalling as a major regulator of nutritional …

Evidence accumulates that the functional plasticity of insulin and insulin-like growth factor
signaling in insects could spring, among others, from the multiplicity of insulin receptors …

A single insulin receptor (InR) gene has been identified and extensively studied in model
species ranging from nematodes to mice. However, most insects possess additional copies …

Since practically a century ago, the insulin pathway was discovered in both vertebrates and
invertebrates, implying an evolutionarily ancient origin. After a century of research, it is now …

The insulin receptor (IR), the insulin‐like growth factor‐1 receptor (IGF1R), and the
insulin/IGF1 hybrid receptors (hybR) are homologous transmembrane receptors. The …

Phenotypic plasticity is a fundamental property of developing organisms and is thought to
play an important role in diversification. Plastic responses themselves are remarkably …

The insulin signaling (IIS) pathway plays an important role in the metabolism, growth,
development, reproduction, and longevity of an organism. As a key member of the IIS …