Recent breakthroughs and future directions in drugging aquaporins
Aquaporins facilitate the passive transport of water, solutes, or ions across biological
membranes. They are implicated in diverse pathologies including brain edema following …
membranes. They are implicated in diverse pathologies including brain edema following …
Neuron-astrocyte omnidirectional signaling in neurological health and disease
D Pathak, K Sriram - Frontiers in molecular neuroscience, 2023 - frontiersin.org
Astrocytes are an abundantly distributed population of glial cells in the central nervous
system (CNS) that perform myriad functions in the normal and injured/diseased brain …
system (CNS) that perform myriad functions in the normal and injured/diseased brain …
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …
Military traumatic brain injury: a challenge straddling neurology and psychiatry
LZ Kong, RL Zhang, SH Hu, JB Lai - Military medical research, 2022 - Springer
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible
effect of the war. In this review, we begin by examining related military research …
effect of the war. In this review, we begin by examining related military research …
The water transport system in astrocytes–Aquaporins
Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …
cell membranes, including those of astrocytes. The expression and subcellular localization …
[HTML][HTML] Molecular mechanisms governing aquaporin relocalisation
A Markou, L Unger, M Abir-Awan, A Saadallah… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the
movement of water across biological membrane by osmosis, as well as facilitating the …
movement of water across biological membrane by osmosis, as well as facilitating the …
Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury
M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …
Astrocytes in functional recovery following central nervous system injuries
Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms
critical for regulating neuronal plasticity following central nervous system (CNS) insults …
critical for regulating neuronal plasticity following central nervous system (CNS) insults …
Endothelial dysfunction in neurodegenerative diseases
YC Fang, YC Hsieh, CJ Hu, YK Tu - International journal of molecular …, 2023 - mdpi.com
The cerebral vascular system stringently regulates cerebral blood flow (CBF). The
components of the blood–brain barrier (BBB) protect the brain from pathogenic infections …
components of the blood–brain barrier (BBB) protect the brain from pathogenic infections …
[HTML][HTML] Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson's disease
Introduction The glymphatic system offers a perivascular pathway for the clearance of
pathological proteins and metabolites to optimize neurological functions. Glymphatic …
pathological proteins and metabolites to optimize neurological functions. Glymphatic …