Recent breakthroughs and future directions in drugging aquaporins

MM Salman, P Kitchen, AJ Yool, RM Bill - Trends in pharmacological …, 2022 - cell.com
Aquaporins facilitate the passive transport of water, solutes, or ions across biological
membranes. They are implicated in diverse pathologies including brain edema following …

Neuron-astrocyte omnidirectional signaling in neurological health and disease

D Pathak, K Sriram - Frontiers in molecular neuroscience, 2023 - frontiersin.org
Astrocytes are an abundantly distributed population of glial cells in the central nervous
system (CNS) that perform myriad functions in the normal and injured/diseased brain …

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

RS Gomolka, LM Hablitz, H Mestre, M Giannetto, T Du… - Elife, 2023 - elifesciences.org
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …

Military traumatic brain injury: a challenge straddling neurology and psychiatry

LZ Kong, RL Zhang, SH Hu, JB Lai - Military medical research, 2022 - Springer
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible
effect of the war. In this review, we begin by examining related military research …

The water transport system in astrocytes–Aquaporins

Z Zhou, J Zhan, Q Cai, F Xu, R Chai, K Lam, Z Luan… - Cells, 2022 - mdpi.com
Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …

[HTML][HTML] Molecular mechanisms governing aquaporin relocalisation

A Markou, L Unger, M Abir-Awan, A Saadallah… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the
movement of water across biological membrane by osmosis, as well as facilitating the …

Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …

Astrocytes in functional recovery following central nervous system injuries

QM Alhadidi, GA Bahader, O Arvola… - The Journal of …, 2024 - Wiley Online Library
Astrocytes are increasingly recognised as partaking in complex homeostatic mechanisms
critical for regulating neuronal plasticity following central nervous system (CNS) insults …

Endothelial dysfunction in neurodegenerative diseases

YC Fang, YC Hsieh, CJ Hu, YK Tu - International journal of molecular …, 2023 - mdpi.com
The cerebral vascular system stringently regulates cerebral blood flow (CBF). The
components of the blood–brain barrier (BBB) protect the brain from pathogenic infections …

[HTML][HTML] Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson's disease

X Si, S Dai, Y Fang, J Tang, Z Wang, Y Li… - Journal of advanced …, 2024 - Elsevier
Introduction The glymphatic system offers a perivascular pathway for the clearance of
pathological proteins and metabolites to optimize neurological functions. Glymphatic …