The adaptive immune response to influenza virus infection is multifaceted and complex,
involving antibody and cellular responses at both systemic and mucosal levels. Immune …

Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

Influenza vaccines could be improved by platforms inducing cross-reactive immunity.
Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines …

Current yearly seasonal influenza vaccines primarily induce an antibody response directed
against the immunodominant but continually diversifying hemagglutinin (HA) head region …

Generating a broadly protective influenza vaccine is critical to global health. Understanding
how immune memory influences influenza immunity is central to this goal. We undertook an …

Antibody responses are essential for protection against influenza virus infection. Humans
are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that …

Antigen-specific B cells bifurcate into antibody-secreting cells (ASCs) and memory B cells
(MBCs) after infection or vaccination. ASCs (plasmablasts) have been extensively studied in …

There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal
coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding …

Highlights•Hemagglutinin stalk-reactive monoclonal antibodies are able to neutralize
divergent influenza virus strains.•Stalk-reactive antibodies are currently being tested in …

Influenza infection imparts an age-related increase in mortality and morbidity. The most
effective countermeasure is vaccination; however, vaccines offer modest protection in older …