Emotions arise from activations of specialized neuronal populations in several parts of the
cerebral cortex, notably the anterior cingulate, insula, ventromedial prefrontal, and …

The incentive salience sensitization (ISS) theory of addiction holds that addictive behavior
stems from the ability of drugs to progressively sensitize the brain circuitry that mediates …

Projections of ventral tegmental area dopamine (DA) neurons to the medial shell of the
nucleus accumbens have been increasingly implicated as integral to the behavioral and …

We present a mean-field formalism able to predict the collective dynamics of large networks
of conductance-based interacting spiking neurons. We apply this formalism to several …

Rho GTPases family are considered to be molecular switches that regulate various cellular
processes, including cytoskeleton remodeling, cell polarity, synaptic development and …

Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and
severe alcoholism in JAMA, there has been an explosion of genetic candidate association …

Addiction is a chronic and potentially deadly disease considered a global health problem.
Nevertheless, there is still no ideal treatment for its management. The alterations in the …

According to a popular hypothesis, phasic dopamine (DA) activity encodes a reward
prediction error (RPE) necessary for reinforcement learning. However, recent work showed …

The use and abuse of psychoactive substances by humans is at least as old as our ability to
document our own existence, recurring as it does in some of the earliest known human texts …

AIM: To study the efficacy of pregabalin for relapse prevention and reduction of drinking in
patients with alcohol dependence. MATERIAL AND METHODS: One hundred recently …